Naloxone sensitive orphanin FQ-induced analgesia in mice Journal Article
| Authors: | Rossi, G. C.; Leventhal, L.; Pasternak, G. W. |
| Article Title: | Naloxone sensitive orphanin FQ-induced analgesia in mice |
| Abstract: | Orphanin FQ, also known as nociceptin, is a heptadecapeptide with very high affinity for a novel member of the cloned opioid receptor family which produces hyperalgesia in mice. In addition to hyperalgesia, which is observed soon after administration of orphanin FQ, we now describe a delayed analgesic response. Unlike orphanin FQ-induced hyperalgesia, orphanin FQ-induced analgesia is readily reversed by the opioid antagonist naloxone, implying an opioid mechanism of action. In view of the very poor affinity of orphanin FQ for all the known traditional opioid receptors and the low affinity of opioids for the 125I[Tyr14]orphanin FQ binding site, orphanin FQ-induced analgesia is probably mediated through a novel orphanin FQ receptor subtype. |
| Keywords: | controlled study; nonhuman; mouse; animals; mice; animal experiment; drug receptor binding; pain measurement; analgesia; hyperalgesia; naloxone; opiate receptor; opioid peptides; receptor subtype; nociceptin; opiate peptide; narcotic antagonists; subcutaneous drug administration; receptors, opioid; intracerebroventricular drug administration; male; priority journal; article; orphanin fq |
| Journal Title: | European Journal of Pharmacology |
| Volume: | 311 |
| Issue: | 2-3 |
| ISSN: | 0014-2999 |
| Publisher: | Elsevier B.V. |
| Date Published: | 1996-09-12 |
| Start Page: | R7 |
| End Page: | R8 |
| Language: | English |
| DOI: | 10.1016/0014-2999(96)00578-x |
| PUBMED: | 8891615 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
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