Total syntheses of CP-225,917 and CP-263,114: Creation of a matrix structure by sequential aldol condensation and intramolecular Heck ring closure Journal Article

  


Authors: Kwon, O.; Su, D. S.; Meng, D.; Deng, W.; D'Amico, D. C.; Danishefsky, S. J.
Article Title: Total syntheses of CP-225,917 and CP-263,114: Creation of a matrix structure by sequential aldol condensation and intramolecular Heck ring closure
Abstract: Important progress towards the total syntheses of the title compounds, potent inhibitors of squalene synthase and farnesyl transferase, has been accomplished by the construction of the highly functionalized compound 1.
Keywords: natural products; synthetic methods; aldol reactions; heck reactions
Journal Title: Angewandte Chemie - International Edition
Volume: 37
Issue: 13-14
ISSN: 1433-7851
Publisher: Wiley Blackwell  
Date Published: 1998-08-03
Start Page: 1877
End Page: 1880
Language: English
PROVIDER: scopus
DOI: 10.1002/(SICI)1521-3773(19980803)37:13/14<1877::AID-ANIE1877>3.0.CO;2-2
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032479724&partnerID=40&md5=a5595850c8ad940452f68a6c6ebf7caa
Notes: Article -- Export Date: 12 December 2016 -- Source: Scopus
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MSK Authors
  1. Samuel J Danishefsky
    539 Danishefsky
  2. Dongfang Meng
    17 Meng
  3. Dai-Shi Su
    12 Su
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