The synthesis of CP-263,114 and CP-225,917: Striking long-range stereocontrol in the fashioning of C7 Journal Article
| Authors: | Tan, Q.; Danishefsky, S. J. |
| Article Title: | The synthesis of CP-263,114 and CP-225,917: Striking long-range stereocontrol in the fashioning of C7 |
| Abstract: | More remote influences: The substitute at C1 in 1 can control the course of attack during addition of a nucleophile to the C7 aldehyde. This stereochemical guidance proved an interesting challenge in the synthesis of the title compounds. |
| Keywords: | signal transduction; unclassified drug; thermodynamics; ras protein; chemical structure; molecular interaction; natural product; metabolite; reaction analysis; synthesis; fungal protein; carbon; natural products; fermentation; aldehyde; asymmetric synthesis; reaction mechanisms; phomoidride b; article; farnesyl trans transferase; synthesis design; polycycles; cp 255917; squalene synthase |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 39 |
| Issue: | 24 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2000-12-15 |
| Start Page: | 4509 |
| End Page: | 4511 |
| Language: | English |
| DOI: | 10.1002/1521-3773(20001215)39:24<4509::aid-anie4509>3.0.co;2-f |
| PROVIDER: | scopus |
| PUBMED: | 11169652 |
| DOI/URL: | |
| Notes: | Corrigendum issued, see DOI: 10.1002/1521-3773(20010216)40:4<647::AID-ANIE6473>3.0.CO;2-G -- Export Date: 18 November 2015 -- Source: Scopus |
