Stereospecific sulfur-mediated cleavage of a spirocyclobutanone: Synthesis of a fully functional precursor to the CP compounds Journal Article
| Authors: | Meng, D.; Danishefsky, S. J. |
| Article Title: | Stereospecific sulfur-mediated cleavage of a spirocyclobutanone: Synthesis of a fully functional precursor to the CP compounds |
| Abstract: | A reaction sequence made up of a Sakurai reaction, ketene cyclization, sulfur-directed Baeyer-Villiger reaction, and tandem lactone cleavage/isomerization provided the fully functionalized core of the CP compounds. Key steps were the methanolysis of 1, which leads via 2 to the CP precursor 3. |
| Keywords: | unclassified drug; drug structure; drug synthesis; structure activity relation; cyclization; natural product; oxidation; reaction analysis; stereospecificity; chemical bond; natural products; hydroxylation; cyclobutanone derivative; isomerism; synthetic methods; decomposition; article; polycycles; 2 butanone; cp 225917; cp 263114; spirocyclobutanone |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 38 |
| Issue: | 10 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1999-05-17 |
| Start Page: | 1485 |
| End Page: | 1488 |
| Language: | English |
| PROVIDER: | scopus |
| DOI: | 10.1002/(SICI)1521-3773(19990517)38:10<1485::AID-ANIE1485>3.0.CO;2-1 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
