Multi-BRCT scaffolds use distinct strategies to support genome maintenance Journal Article


Authors: Wan, B.; Hang, L. E.; Zhao, X.
Article Title: Multi-BRCT scaffolds use distinct strategies to support genome maintenance
Abstract: Genome maintenance requires coordinated actions of diverse DNA metabolism processes. Scaffolding proteins, such as those containing multiple BRCT domains, can influence these processes by collaborating with numerous partners. The best-studied examples of multi-BRCT scaffolds are the budding yeast Dpb11 and its homologues in other organisms, which regulate DNA replication, repair, and damage checkpoints. Recent studies have shed light on another group of multi-BRCT scaffolds, including Rtt107 in budding yeast and related proteins in other organisms. These proteins also influence several DNA metabolism pathways, though they use strategies unlike those employed by the Dpb11 family of proteins. Yet, at the same time, these 2 classes of multi-BRCT proteins can collaborate under specific situations. This review summarizes recent advances in our understanding of how these multi-BRCT proteins function in distinct manners and how they collaborate, with a focus on Dpb11 and Rtt107. © 2016 Taylor & Francis.
Keywords: unclassified drug; review; nonhuman; comparative study; ubiquitin; dna replication; protein function; ubiquitin protein ligase; protein protein interaction; brca1 protein; amino terminal sequence; histone; dna metabolism; sumo protein; dpb11 protein; topbp1 protein; cullin; sumo; recombination; budding yeast; dna damage checkpoint; scaffold protein; fungal genome; recombination repair; smc5 protein; smc6 protein; brct; rtt107; dpb11; cut5 protein; rtt107 protein; slx4 protein
Journal Title: Cell Cycle
Volume: 15
Issue: 19
ISSN: 1538-4101
Publisher: Taylor & Francis Inc.  
Date Published: 2016-08-11
Start Page: 2561
End Page: 2570
Language: English
DOI: 10.1080/15384101.2016.1218102
PROVIDER: scopus
PMCID: PMC5053572
PUBMED: 27580271
DOI/URL:
Notes: Review -- Export Date: 1 November 2016 -- Source: Scopus
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MSK Authors
  1. Xiaolan Zhao
    55 Zhao
  2. Lisa Eileen Hang
    9 Hang
  3. Bingbing   Wan
    3 Wan