Synapse - Shawn Stachel

Results (13)

Total synthesis as a resource in the discovery of potentially valuable antitumor agents: Cycloproparadicicol

Journal Article

Yamamoto, K.; Garbaccio, R. M.; Stachel, S. J.; Solit, D. B.; Chiosis, G.; Rosen, N.; Danishefsky, S. J.
Angewandte Chemie - International Edition (2003)

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Probing the SAR of dEpoB via chemical synthesis: A total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B

Journal Article

Chappell, M. D.; Harris, C. R.; Kuduk, S. D.; Balog, A.; Wu, Z.; Zhang, F.; Lee, C. B.; Stachel, S. J.; Danishefsky, S. J.; Chou, T. C.; more...
Journal of Organic Chemistry (2002)

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New class of microtubule targeting antitumor agents: Desoxyepothilone B (dEpoB) and desoxyepothilone F (dEpoF)

Meeting Abstract

Chou, T. C.; Guan, Y. B.; Zhang, X. G.; Lee, C.; Stachel, S. J.; Bertino, J. R.; Danishefsky, S. J.
Proceedings of the American Association for Cancer Research Annual Meeting (2001)

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Stability and toxicity of 12,13-desoxyepothilone (dEpoB) in dogs with spontaneous tumors

Meeting Abstract

O'connor, O.; Bergman, P.; Hohenhaus, A.; Tong, W. P. Y.; Bertino, J.; Stachel, S.; Danishefsky, S.
Proceedings of the American Association for Cancer Research Annual Meeting (2001)

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Chemo- and stereoselective epoxidation of 12,13-desoxyepothilone B using 2,2′-dimethyldioxirane

Journal Article

Stachel, S. J.; Danishefsky, S. J.
Tetrahedron Letters (2001)

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The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: Curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice

Journal Article

Chou, T. C.; O'Connor, O. A.; Tong, W. P.; Guan, Y.; Zhang, Z. G.; Stachel, S. J.; Lee, C.; Danishefsky, S. J.
Proceedings of the National Academy of Sciences of the United States of America (2001)

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Concise asymmetric syntheses of radicicol and monocillin I

Journal Article

Garbaccio, R. M.; Stachel, S. J.; Baeschlin, D. K.; Danishefsky, S. J.
Journal of the American Chemical Society (2001)

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Insights into long-range structural effects on the stereochemistry of aldol condensations: A practical total synthesis of desoxyepothilone F

Journal Article

Lee, C. B.; Wu, Z.; Zhang, F.; Chappell, M. D.; Stachel, S. J.; Chou, T. C.; Guan, Y.; Danishefsky, S. J.
Journal of the American Chemical Society (2001)

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On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: Total synthesis and comparative in vivo evaluations of the 15-aza epothilones