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Michael Jason Hadler

Formats
  1. Meeting Abstract (4)
  2. Journal Article (2)
Groups
  1. Adult Leukemia (2)
  2. Center for Hematologic Malignancies (2)
  3. Center for Molecular Imaging and Biotechnology (2)
  4. Department of Medicine (2)
  5. Executive Committee, Center for Hematologic Malignancies (2)
  6. GSK Faculty (2)

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People
  1. Scott Armstrong (6)
  2. Andrei Krivtsov (4)
  3. Eytan Stein (2)
  4. Kristina Knapp (2)
  5. Michael Kuehn (2)
  6. Ross Levine (2)

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Years
  1. 2015 (2)
  2. 2014 (2)
  3. 2013 (2)
Publications
  1. Blood (4)
  2. ACS Chemical Biology (1)
  3. Haematologica (1)
Publishers
  1. American Society of Hematology (4)
  2. American Chemical Society (1)
  3. Ferrata Storti Foundation (1)

Results (6)

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  • MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition
    Journal Article

    Kühn, M. W. M.; Hadler, M. J.; Daigle, S. R.; Koche, R. P.; Krivtsov, A. V.; Olhava, E. J.; Caligiuri, M. A.; Huang, G.; Bradner, J. E.; Pollock, R. M.; more...
    Haematologica (2015)

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  • Structure-guided DOT1L probe optimization by label-free ligand displacement
    Journal Article

    Yi, J. S.; Federation, A. J.; Qi, J.; Dhe-Paganon, S.; Hadler, M.; Xu, X.; St Pierre, R.; Varca, A. C.; Wu, L.; Marineau, J. J.; more...
    ACS Chemical Biology (2015)

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  • Structure-guided design of DOT1L methyltransferase inhibitors by a novel, label free assay platform
    Meeting Abstract

    Yi, J. S.; Federation, A.; Qi, J.; Dhe-Paganon, S.; Hadler, M.; Xu, X.; Varca, A.; St Pierre, R.; Armstrong, S. A.; Bradner, J. E.
    Blood (2014)

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  • Patient derived xenograft (PDX) models recapitulate the genomic-driver composition of acute leukemia samples
    Meeting Abstract

    Krivtsov, A. V.; Wang, X. J.; Farnoud, N. R.; Hadler, M.; Martin, M. S.; Knapp, K. M.; Stein, E. M.; Lipson, D.; Nahas, M. K.; Stephens, P. J.; more...
    Blood (2014)

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  • Myeloid leukemia cells with MLL partial tandem duplication are sensitive to pharmacological inhibition of the H3K79 methyltransferase DOT1L
    Meeting Abstract

    Kühn, M. W. M.; Hadler, M.; Daigle, S. R.; Chen, C. W.; Sinha, A. U.; Krivtsov, A. V.; Olhava, E. J.; Caligiuri, M. A.; Bradner, J. E.; Pollock, R. M.; more...
    Blood (2013)

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  • Patient derived xenograft (PDX) models faithfully recapitulate the genetic composition of primary AML
    Meeting Abstract

    Krivtsov, A. V.; Xujun, W.; Farnoud, N. R.; Hadler, M.; Knapp, K. M.; Stein, E. M.; Tallman, M. S.; Donahue, A. L.; Lipson, D.; Nahas, M. K.; more...
    Blood (2013)

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