Research Focus

Former Employee. Graduate Staff; NE Medical Student

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1. MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition

   Journal Article

   Kühn, M. W. M.; Hadler, M. J.; Daigle, S. R.; Koche, R. P.; Krivtsov, A. V.; Olhava, E. J.; Caligiuri, M. A.; Huang, G.; Bradner, J. E.; Pollock, R. M.; more...
   Haematologica (2015)

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2. Structure-guided DOT1L probe optimization by label-free ligand displacement

   Journal Article

   Yi, J. S.; Federation, A. J.; Qi, J.; Dhe-Paganon, S.; Hadler, M.; Xu, X.; St Pierre, R.; Varca, A. C.; Wu, L.; Marineau, J. J.; more...
   ACS Chemical Biology (2015)

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3. Structure-guided design of DOT1L methyltransferase inhibitors by a novel, label free assay platform

   Meeting Abstract

   Yi, J. S.; Federation, A.; Qi, J.; Dhe-Paganon, S.; Hadler, M.; Xu, X.; Varca, A.; St Pierre, R.; Armstrong, S. A.; Bradner, J. E.
   Blood (2014)

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