Synapse - Developmental Biology Program Faculty

Generation of human embryonic stem cell models to exploit the EWSR1-CREB fusion promiscuity as a common pathway of transformation in human tumors

CSF1R inhibition depletes tumor-associated macrophages and attenuates tumor progression in a mouse sonic hedgehog-medulloblastoma model

The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumor

Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability

Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks

Homologous repair of DNA damage and tumorigenesis: The BRCA connection

Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks

Expression of the c-kit proto-oncogene in the murine male germ cells

Developmental Biology Program Faculty