Expression of the c-kit proto-oncogene in the murine male germ cells Journal Article
| Authors: | Sorrentino, V.; Giorgi, M.; Geremia, R.; Besmer, P.; Rossi, P. |
| Article Title: | Expression of the c-kit proto-oncogene in the murine male germ cells |
| Abstract: | The proto-oncogene c-kit encodes a transmembrane protein tyrosine kinase receptor. The c-kit gene has recently been shown to be allelic with the W locus. Mutations at the white spotting locus (W) affect various aspects of hematopoiesis, melanogenesis and gametogenesis during development and in the adult animal. We have investigated the expression of the proto-oncogene c-kit in mouse testicular cell populations. The c-kit mRNA was found to be expressed at high levels in spermatogonia, and at lower levels in meiotic pachytene spermatocytes. Moreover, two novel testis-specific c-kit transcripts of 3.5 and 2.3kb are present in postmeiotic haploid germ cells. These results suggest a role of c-kit not only during testis development in the embryo, but also throughout all stages of male germ cell development after birth. |
| Keywords: | controlled study; proto-oncogene proteins; nonhuman; animal cell; mouse; animal; mice; spermatocytes; proto oncogene; gene expression; germ cell; protein tyrosine kinase; animalia; rna, messenger; murinae; blotting, northern; spermatozoa; spermatogonia; protein-tyrosine kinase; male; priority journal; article; support, non-u.s. gov't; proto-oncogene protein c-kit |
| Journal Title: | Oncogene |
| Volume: | 6 |
| Issue: | 1 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 1991-01-01 |
| Start Page: | 149 |
| End Page: | 151 |
| Language: | English |
| PUBMED: | 1704118 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
