Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice - evidence for an impaired c-kit kinase in mutant mice Journal Article
| Authors: | Nocka, K.; Majumder, S.; Chabot, B.; Ray, P.; Cervone, M.; Bernstein, A.; Besmer, P. |
| Article Title: | Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice - evidence for an impaired c-kit kinase in mutant mice |
| Abstract: | The proto-oncogene c-kit, a transmembrane tyrosine protein kinase receptor for an unknown ligand, was shown recently to map to the dominant white spotting locus (W) of the mouse. Mutations at the W locus affect various aspects of hematopoiesis, as well as the proliferation and/or migration of primordial germ cells and melanoblasts during development. Here, we show that c-kit is expressed in tissues known to be affected by W mutations in fetal and adult erythropoietic tissues, mast cells, and neural-crest-derived melanocytes. We demonstrate that the c-kit associated tyrosine-specific protein kinase is functionally impaired in W/WV mast cells, thus providing a molecular basis for understanding the developmental defects that result from these mutations. |
| Keywords: | oncoprotein; genetics; proto-oncogene proteins; mouse; animal; metabolism; mouse mutant; animals; mice; allele; stem cell factor receptor; proto oncogene; proto-oncogene proteins c-kit; melanocyte; melanocytes; mice, mutant strains; alleles; cell motion; enzymology; pathology; tumor cells, cultured; protein tyrosine kinase; heterozygote; prenatal development; liver; biosynthesis; cell culture; messenger rna; rna, messenger; organ specificity; hematopoietic stem cells; experimental melanoma; melanoma, experimental; pigmentation disorders; cell movement; antibody specificity; hematopoiesis; protein-tyrosine kinases; neural crest; hematopoietic stem cell; lethal gene; genes, lethal; pigment disorder; mast cell; mast cells; proto-oncogenes; macrocytic anemia; article; embryonic and fetal development; anemia, macrocytic |
| Journal Title: | Genes and Development |
| Volume: | 3 |
| Issue: | 6 |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 1989-06-01 |
| Start Page: | 816 |
| End Page: | 826 |
| Language: | English |
| DOI: | 10.1101/gad.3.6.816 |
| PUBMED: | 2473008 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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