Homologous repair of DNA damage and tumorigenesis: The BRCA connection Journal Article
| Author: | Jasin, M. |
| Article Title: | Homologous repair of DNA damage and tumorigenesis: The BRCA connection |
| Abstract: | Homologous recombination has been recognized in recent years to be an important DNA repair pathway in mammalian cells, for such damage as chromosomal double-strand breaks. Cells mutated for the genes involved in the hereditary breast and ovarian cancer susceptibility syndromes, i.e. BRCA1 and BRCA2, show defects in DNA repair by homologous recombination, implicating this repair pathway in protecting individuals against tumorigenesis. This review summarizes recent advances in our understanding of BRCA1 and BRCA2 in DNA repair, as well as insight into these proteins gleaned from structure determination of domains of these proteins and the broader evolutionary conservation than previously appreciated. |
| Keywords: | gene mutation; mutation; dna-binding proteins; review; protein domain; neoplasms; ovarian neoplasms; mammalia; animals; dna damage; homologous recombination; dna repair; cancer susceptibility; ovary cancer; breast cancer; evolution; breast neoplasms; brca1 protein; brca2 protein; carcinogenesis; dna; amino acid sequence; conserved sequence; recombination, genetic; carrier proteins; tumor suppressor proteins; chromosome breakage; familial cancer; protein structure; structure analysis; ubiquitin-protein ligases; brca1; brca2; rad51 protein; rad51 recombinase; rad51; humans; human; female; priority journal |
| Journal Title: | Oncogene |
| Volume: | 21 |
| Issue: | 58 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2002-12-16 |
| Start Page: | 8981 |
| End Page: | 8993 |
| Language: | English |
| DOI: | 10.1038/sj.onc.1206176 |
| PUBMED: | 12483514 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
