Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis Journal Article
| Authors: | Moynahan, M. E.; Jasin, M. |
| Article Title: | Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis |
| Abstract: | Mitotic homologous recombination promotes genome stability through the precise repair of DNA double-strand breaks and other lesions that are encountered during normal cellular metabolism and from exogenous insults. As a result, homologous recombination repair is essential during proliferative stages in development and during somatic cell renewal in adults to protect against cell death and mutagenic outcomes from DNA damage. Mutations in mammalian genes encoding homologous recombination proteins, including BRCA1, BRCA2 and PALB2, are associated with developmental abnormalities and tumorigenesis. Recent advances have provided a clearer understanding of the connections between these proteins and of the key steps of homologous recombination and DNA strand exchange. © 2010 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | unclassified drug; mutation; review; neoplasms; cell proliferation; mitosis; mammalia; animals; cell death; dna damage; homologous recombination; dna repair; models, biological; gene function; cell renewal; brca1 protein; brca2 protein; carcinogenesis; cancer inhibition; recombination, genetic; genomic instability; dna breaks, double-stranded; dna breaks, single-stranded; genome; cell metabolism; mutagenesis; palb2 protein; dna strand |
| Journal Title: | Nature Reviews Molecular Cell Biology |
| Volume: | 11 |
| Issue: | 3 |
| ISSN: | 1471-0072 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2010-03-01 |
| Start Page: | 196 |
| End Page: | 207 |
| Language: | English |
| DOI: | 10.1038/nrm2851 |
| PUBMED: | 20177395 |
| PROVIDER: | scopus |
| PMCID: | PMC3261768 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 26" - "Export Date: 20 April 2011" - "CODEN: NRMCB" - "Source: Scopus" |
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