Epigenetic regulation of hematopoietic stem cell development Journal Article


Authors: Li, C.; Evans, T.; Goll, M. G.
Article Title: Epigenetic regulation of hematopoietic stem cell development
Abstract: Hematopoietic stem cells (HSCs) are multipotent self-renewing precursors with the capacity to differentiate into all adult blood cell lineages. HSC development is a highly orchestrated process regulated by multiple transcription factors and signaling pathways. Emerging evidence suggests that epigenetic regulation is an additional essential component of HSC development. Powerful genetic and imaging approaches, combined with conservation of mammalian programs, have made zebrafish a prominent model for the study of HSC production. This chapter summarizes approaches that have been used to identify epigenetic regulators of HSC development in zebrafish and highlights additional strategies that are likely to facilitate progress in this promising field. © 2016 Elsevier Inc.
Keywords: genetics; dna methylation; zebrafish; acetylation; embryogenesis; hemogenic endothelium; hydroxymethylcytosine; tet genes
Journal Title: Methods in Cell Biology
Volume: 135
ISSN: 0091-679X
Publisher: Academic Press, Elsevier Inc  
Date Published: 2016-01-01
Start Page: 431
End Page: 448
Language: English
DOI: 10.1016/bs.mcb.2016.01.010
PROVIDER: scopus
PUBMED: 27443939
DOI/URL:
Notes: Article -- Chapter 22 in "The Zebrafish: Genetics, Genomics, and Transcriptomics" (ISBN: 978-0-12-803474-3) -- Export Date: 3 October 2016 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Mary Grace Goll
    6 Goll
  2. Chen Li
    6 Li