Zebrafish cancer: The state of the art and the path forward Journal Article
| Authors: | White, R.; Rose, K.; Zon, L. |
| Article Title: | Zebrafish cancer: The state of the art and the path forward |
| Abstract: | The zebrafish is a recent addition to animal models of human cancer, and studies using this model are rapidly contributing major insights. Zebrafish develop cancer spontaneously, after mutagen exposure and through transgenesis. The tumours resemble human cancers at the histological, gene expression and genomic levels. The ability to carry out in vivo imaging, chemical and genetic screens, and high-throughput transgenesis offers a unique opportunity to functionally characterize the cancer genome. Moreover, increasingly sophisticated modelling of combinations of genetic and epigenetic alterations will allow the zebrafish to complement what can be achieved in other models, such as mouse and human cell culture systems. © 2013 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | acute granulocytic leukemia; gene mutation; pathogenesis; review; liver cell carcinoma; nonhuman; pancreas cancer; phenotype; cancer immunotherapy; melanoma; embryo development; in vivo study; tumor xenograft; cancer model; cancer research; acute lymphoblastic leukemia; carcinogenesis; ewing sarcoma; tumor suppressor gene; t cell lymphoma; neuroblastoma; epigenetics; genomics; chemical genetics; rhabdomyosarcoma; genetic screening; germ cell tumor; malignant peripheral nerve sheath tumor; t cell leukemia; mutagenesis; zebra fish; myeloproliferative neoplasm; transgenics; cancer transplantation; b cell leukemia; lipoma; tumor microenvironment; phase 2 clinical trial (topic); teratogenicity; phase 1 clinical trial (topic); developmental genetics; pancreatic neuroendocrine tumor; vemurafenib; xenotransplantation; leflunomide; acth secreting adenoma; reverse genetics |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 13 |
| Issue: | 9 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2013-09-01 |
| Start Page: | 624 |
| End Page: | 636 |
| Language: | English |
| DOI: | 10.1038/nrc3589 |
| PROVIDER: | scopus |
| PUBMED: | 23969693 |
| PMCID: | PMC6040891 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2013" - "CODEN: NRCAC" - "Source: Scopus" |
