Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells Conference Paper
| Authors: | Subbaramaiah, K.; Michaluart, P.; Chung, W. J.; Tanabe, T.; Telang, N.; Dannenberg, A. J. |
| Title: | Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells |
| Conference Title: | Strang International Cancer Prevention Conference |
| Abstract: | A large body of evidence suggests that inhibiting cyclooxygenase-2 (COX-2), the inducible form of COX, will be an important strategy for preventing cancer. In this study, we investigated whether resveratrol, a chemopreventive agent found in grapes, could suppress phorbol ester (PMA)-mediated induction of COX-2 in human mammary and oral epithelial cells. Treatment of cells with PMA induced COX-2 mRNA, COX-2 protein, and prostaglandin synthesis. These effects were inhibited by resveratrol. Nuclear runoffs revealed increased rates of COX-2 transcription after treatment with PMA, an effect that was inhibited by resveratrol. Resveratrol inhibited PMA-mediated activation of protein kinase C and the induction of COX-2 promoter activity by c-Jun. Phorbol ester-mediated induction of AP-1 activity was blocked by resveratrol. These data are likely to be important for understanding the anticancer and anti-inflammatory properties of resveratrol. |
| Keywords: | controlled study; human cell; promoter region; conference paper; cancer prevention; enzyme inhibition; breast; cell line; antineoplastic agents, phytogenic; membrane proteins; transcription, genetic; antineoplastic activity; drug structure; enzyme inhibitor; enzyme inhibitors; cyclooxygenase 2; prostaglandin; breast epithelium; epithelium cell; epithelial cells; protein kinase c; antiinflammatory activity; gene induction; resveratrol; mouth mucosa; isoenzymes; phorbol ester; enzyme induction; prostaglandin synthesis; transcription factor ap 1; protein c jun; prostaglandin-endoperoxide synthases; prostaglandin synthase inhibitor; stilbenes; humans; human; female; vitaceae |
| Journal Title | Annals of the New York Academy of Sciences |
| Volume: | 889 |
| Conference Dates: | 1998 Nov 13-14 |
| Conference Location: | New York, NY |
| ISBN: | 0077-8923 |
| Publisher: | John Wiley & Sons |
| Date Published: | 1999-10-01 |
| Start Page: | 214 |
| End Page: | 223 |
| Language: | English |
| PUBMED: | 10668496 |
| PROVIDER: | scopus |
| DOI: | 10.1111/j.1749-6632.1999.tb08737.x |
| DOI/URL: | |
| Notes: | Article in "Cancer Prevention: Novel Nutrient and Pharmaceutical Developments" (ISBN: 9781573311984) -- Conference Paper -- Export Date: 16 August 2016 -- Source: Scopus |
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