Peripheral blockade of topical morphine tolerance by ketamine Journal Article
| Authors: | Kolesnikov, Y. A.; Pasternak, G. W. |
| Article Title: | Peripheral blockade of topical morphine tolerance by ketamine |
| Abstract: | Repeated topical administration of morphine daily produces tolerance within three days. Ketamine alone has little effect in the radiant heat tailflick assay. However, with administered with morphine, topical ketamine prevented the development of morphine tolerance in a dose-dependent manner. Furthermore, topical ketamine also slowly reversed pre-existing morphine tolerance. These observations imply that topical morphine tolerance is mediated, at least in part, through peripheral N-methyl-d-aspartate (NMDA) receptors and raises the possibility of the use of topical NMDA receptor antagonists clinically. Copyright (C) 1999 Elsevier Science B.V. |
| Keywords: | controlled study; dose response; nonhuman; mouse; animals; mice; animal experiment; administration, topical; drug effect; dose-response relationship, drug; time factors; short survey; morphine; opioid; analgesia; drug tolerance; drug interactions; morphine tolerance; tail flick test; ketamine; peripheral; n methyl dextro aspartic acid receptor; nmda receptor; receptors, n-methyl-d-aspartate; topical drug administration; priority journal |
| Journal Title: | European Journal of Pharmacology |
| Volume: | 374 |
| Issue: | 2 |
| ISSN: | 0014-2999 |
| Publisher: | Elsevier B.V. |
| Date Published: | 1999-06-18 |
| Start Page: | R1 |
| End Page: | R2 |
| Language: | English |
| DOI: | 10.1016/s0014-2999(99)00318-0 |
| PUBMED: | 10422774 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Short Survey -- Export Date: 16 August 2016 -- Source: Scopus |
