Blockade of morphine-induced hindlimb myoclonic seizures in mice by ketamine Journal Article

  


Authors: Kolesnikov, Y.; Jain, S.; Wilson, R.; Pasternak, G. W.
Article Title: Blockade of morphine-induced hindlimb myoclonic seizures in mice by ketamine
Abstract: Morphine administration can lead to a variety of side-effects, including myoclonus. In an animal model, high morphine doses given intrathecally elicit hindlimb myoclonic seizures which are not influenced by traditional opioid receptor antagonists, such as naloxone. Ketamine prevents this seizure-like activity in a dose-dependent manner. The response is stereoselective, with S-ketamine far more potent than R-ketamine. A competitive NMDA antagonist, NPC17742, also prevents the seizures, although less potently than ketamine. Dextromethorphan has limited activity in this model, while haloperidol and pentothal are without any effect.
Keywords: controlled study; nonhuman; mouse; animals; mice; haloperidol; animal experiment; animal model; dose-response relationship, drug; animalia; mice, inbred strains; seizure; amino acids; morphine; myoclonus; analgesics, opioid; disease models, animal; epilepsy; stereoisomerism; naloxone; ketamine; thiopental; opioid receptor; receptors, n-methyl-d-aspartate; intraperitoneal drug administration; excitatory amino acid antagonists; hindlimb; mu receptor; subcutaneous drug administration; n methyl dextro aspartic acid receptor blocking agent; male; priority journal; article; dextromethorphan; intrathecal drug administration; 2 amino 4,5 (1,2 cyclohexyl) 7 phosphonoheptanoic acid; epilepsies, myoclonic
Journal Title: Pharmacology Biochemistry and Behavior
Volume: 56
Issue: 3
ISSN: 0091-3057
Publisher: Pergamon-Elsevier Science Ltd  
Date Published: 1997-03-01
Start Page: 423
End Page: 425
Language: English
DOI: 10.1016/s0091-3057(96)00221-3
PUBMED: 9077578
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030964840&doi=10.1016%2fS0091-3057%2896%2900221-3&partnerID=40&md5=ff9bd7985bbd89f9ce563f9f3ed2f7a1
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
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MSK Authors
  1. Roger S Wilson
    38 Wilson
  2. Yuri Alexei Kolesnikov
    34 Kolesnikov
  3. Gavril W Pasternak
    414 Pasternak
  4. Subhash Jain
    23 Jain
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