N(G)-nitro-L-arginine prevents morphine tolerance Journal Article
| Authors: | Kolesnikov, Y. A.; Pick, C. G.; Pasternak, G. W. |
| Article Title: | N(G)-nitro-L-arginine prevents morphine tolerance |
| Abstract: | NMDA receptor antagonists, such as MK-801, prevent the development of tolerance to morphine. Since many NMDA actions involve the production of nitric oxide, we examined the effects of a nitric oxide synthase inhibitor on morphine tolerance. The analgesic response to morphine (5 mg/kg s.c.) given daily diminishes from 60% in naive animals to 0% within 5 days. Coadministration of NG-nitro-L-arginine (8 mg/kg per day) along with morphine prevents the demonstration of appreciable tolerance for at least 11 days. These results suggest that morphine tolerance involves the activation of NMDA receptors followed by the subsequent release of nitric oxide. © 1992. |
| Keywords: | controlled study; nonhuman; mouse; animal; metabolism; mice; animal experiment; drug effect; physiology; drug derivative; morphine; analgesia; drug tolerance; arginine; morphine tolerance; tail flick test; nitroarginine; n methyl dextro aspartic acid receptor; nitric oxide; receptors, n-methyl-d-aspartate; intraperitoneal drug administration; subcutaneous drug administration; male; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; n(g) nitroarginine; nitric oxide (no); nmda receptor antagonists; no synthase; receptors, n methyl d aspartate |
| Journal Title: | European Journal of Pharmacology |
| Volume: | 221 |
| Issue: | 2-3 |
| ISSN: | 0014-2999 |
| Publisher: | Elsevier B.V. |
| Date Published: | 1992-09-22 |
| Start Page: | 399 |
| End Page: | 400 |
| Language: | English |
| DOI: | 10.1016/0014-2999(92)90732-j |
| PUBMED: | 1426018 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
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414Pasternak -
14Pick
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