Monoclonal antibodies: Will they become an integral part of the evaluation and treatment of prostate cancer - focus on prostate-specific membrane antigen? Journal Article
| Authors: | Chang, S. S.; Bander, N. H.; Heston, W. D. W. |
| Article Title: | Monoclonal antibodies: Will they become an integral part of the evaluation and treatment of prostate cancer - focus on prostate-specific membrane antigen? |
| Abstract: | Over the past two decades, monoclonal antibody technology has had an increasing impact on clinical diagnostic and therapeutic options, and this is true in the realm of managing prostate cancer. Several targets such as prostate-specific antigen and prostatic acid phosphatase as well as, more recently, angiogenic antigens such as vascular endothelial growth factor have been examined for therapy. Prostate-specific membrane antigen, a type II integral membrane glycoprotein initially characterized by the monoclonal antibody 7E11, has shown promise. Recent evidence suggests that prostate-specific membrane antigen is also expressed in tumor-associated neovasculature of a wide variety of malignant neoplasms. With its expression in prostate secretory-acinar epithelium and the prostate and in the neovasculature associated with tumors, prostate-specific membrane antigen represents an excellent antigenic target for monoclonal antibody diagnostic and therapeutic options. As research continues, the role of monoclonal antibody imaging and therapy will become increasingly important in the management of prostate cancer. |
| Keywords: | vasculotropin; protein expression; prostate specific antigen; monoclonal antibody; prostate cancer; prostate-specific antigen; prostatic neoplasms; antibodies, monoclonal; antigens, neoplasm; membrane protein; organ specificity; short survey; antibody specificity; tumor vascularization; antigens, surface; acid phosphatase prostate isoenzyme; humans; human; male; priority journal |
| Journal Title: | Current Opinion in Urology |
| Volume: | 9 |
| Issue: | 5 |
| ISSN: | 0963-0643 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1999-09-01 |
| Start Page: | 391 |
| End Page: | 395 |
| Language: | English |
| DOI: | 10.1097/00042307-199909000-00004 |
| PUBMED: | 10579076 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Short Survey -- Export Date: 16 August 2016 -- Source: Scopus |
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