Rising PSAs after primary therapy: Active or passive intervention Journal Article
| Authors: | Slovin, S. F.; Scher, H. I. |
| Article Title: | Rising PSAs after primary therapy: Active or passive intervention |
| Abstract: | Prostate cancer that has relapsed biochemically after primary therapies, such as prostatectomy or radiation, remains a therapeutic challenge in that no standard treatment option exists for this patient. These patients are often young and may be offered androgen ablation as the mainstay of treatment. Many patients do not wish to undergo a regimen that may be associated with a variety of side effects that will impact on their quality of life. Delaying hormonal treatment in this group does not compromise survival and patients may try a variety of approaches in an attempt to control rising PSAs. Therefore, these patients are an interesting subgroup for whom immunological and alternative therapies may prove to be beneficial. We review new approaches for this population of men, which result in antitumor effects with minimal toxicities. |
| Keywords: | review; prostate specific antigen; interleukin 2; neoplasm recurrence, local; dendritic cell; granulocyte macrophage colony stimulating factor; interleukin 4; interleukin 7; gene transfer; prostate cancer; prostate-specific antigen; prostatic neoplasms; cytokine; cytokines; dendritic cells; gamma interferon; cancer vaccine; cancer vaccines; prostatectomy; vaccination; psa; gene therapy; interleukin 6; plant extract; phytotherapy; selenium; granulocyte colony stimulating factor; intercellular adhesion molecule 1; vaccines; tumor necrosis factor; virus vector; herbal medicine; genistein; vectors; male genital tract cancer; antisense oligonucleotide; diet, fat-restricted; humans; human; male; priority journal; slopes |
| Journal Title: | Seminars in Urologic Oncology |
| Volume: | 17 |
| Issue: | 3 |
| ISSN: | 1081-0943 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 1999-08-01 |
| Start Page: | 164 |
| End Page: | 173 |
| Language: | English |
| PUBMED: | 10462320 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 16 August 2016 -- Source: Scopus |
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