Therapeutic strategies targeting proteins that regulate folate and reduced folate transport Journal Article
| Authors: | Trippett, T. M.; Bertino, J. R. |
| Article Title: | Therapeutic strategies targeting proteins that regulate folate and reduced folate transport |
| Abstract: | Folate is an essential vitamin which acts as a precursor for cofactors that regulate a variety of biochemical reactions. Cellular uptake of endogenous folates as well as antifolate agents such as methotrexate may be regulated by two independent transport proteins, the folate receptor and the reduced folate carrier. This paper reviews the molecular and functional characteristics of these transport systems and potential therapeutic approaches exploiting these targets in the treatment of cancer. Understanding of the molecular basis and functional characteristics of the transport of endogenous folates and folate analogs via the folate receptor and the reduced folate carrier has led to the development of novel antifolate agents through rational drug design and targeted therapeutic approaches for tumors that express or lack the presence of these transport proteins. With this knowledge, new and selective treatment will become available to more effectively treat patients with a variety of malignancies. |
| Keywords: | osteosarcoma; cancer chemotherapy; carrier protein; unclassified drug; review; methotrexate; neoplasms; cancer immunotherapy; antimetabolites, antineoplastic; enzyme activity; drug design; structure activity relation; acute lymphoblastic leukemia; monoclonal antibody; regulatory mechanism; drug mechanism; tissue distribution; folinic acid; carrier proteins; ovary carcinoma; folic acid; receptor affinity; folic acid antagonist; folic acid antagonists; drug transport; isoprotein; reaction analysis; receptors, cell surface; peptide analysis; folate receptor; trimetrexate; reduced folate carrier; transport; folate metabolism; pneumocystosis; folate binding protein; bispecific antibody; folic acid derivative; cancer; humans; human; monoclonal antibody mov 17; monoclonal antibody mov 18; monoclonal antibody mov 19; vitamin receptor |
| Journal Title: | Journal of Chemotherapy |
| Volume: | 11 |
| Issue: | 1 |
| ISSN: | 1120-009X |
| Publisher: | E I F T Srl |
| Date Published: | 1999-01-01 |
| Start Page: | 3 |
| End Page: | 10 |
| Language: | English |
| PUBMED: | 10078775 |
| PROVIDER: | scopus |
| DOI: | 10.1179/joc.1999.11.1.3 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 16 August 2016 -- Source: Scopus |
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