Breast carcinoma in young women: No evidence of increasing rates of metastatic breast carcinoma in a single tertiary center review Journal Article

   

Authors:	Conlon, N.; Howard, J.; Catalano, J.; Gallagher, M.; Tan, L. K.; Corben, A. D.
Article Title:	Breast carcinoma in young women: No evidence of increasing rates of metastatic breast carcinoma in a single tertiary center review
Abstract:	Breast carcinoma in young women aged less than 40 years attracts a high level of mainstream media coverage, and there is a gap between societal perceptions of the disease as a growing problem and epidemiological trends. Several population studies have reported that the overall incidence of breast carcinoma in young women is stable, while one recent article suggested that the relative proportion of breast carcinoma in young women that is metastatic at diagnosis is growing. We sought to establish whether these trends were apparent at our institution. In this study, the clinical database at a breast carcinoma tertiary center was reviewed in terms of clinicopathologic data on patient age, diagnosis, clinical and pathologic stage, hormone receptor status, and HER-2 overexpression status for the period 2000-2011. Over the study period, young patients represented a decreasing proportion of all breast carcinoma cases (10.8% [2000-2003] to 8.7% [2008-2011]; p < 0.0001) treated at our institution. Young patients were more likely than patients aged 40 years or older to present with metastatic (M1) disease (5.4% versus 4.4%; p = 0.009), to be triple negative (21.6% versus 13%; p < 0.001), or to be HER-2 positive (24.3% versus 14.8%; p < 0.01). Young patients with HER-2-positive cancers were significantly more likely to present with metastatic disease (8.3% versus 4.8%; p = 0.004). This study showed no demonstrable increase in the relative proportion of breast cancer occurring in patients aged < 40 years over the 12-year period 2000-2011 and no increase in the proportion of young patients presenting with metastatic disease.
Keywords:	survival; cancer incidence; prevalence; patient age; mutations; preservation; young women; trends; united-states; pathological features; prognosis; metastatic breast carcinoma; her2-positive breast carcinoma
Journal Title:	Breast Journal
Volume:	22
Issue:	3
ISSN:	1075-122X
Publisher:	Wiley Blackwell
Date Published:	2016-05-01
Start Page:	287
End Page:	292
Language:	English
ACCESSION:	WOS:000379817800005
DOI:	10.1111/tbj.12575
PROVIDER:	wos
PUBMED:	26923423
PMCID:	PMC5558606
Notes:	Review -- Source: Wos

https://synapse.mskcc.org/synapse/works/has_related_data_chk/96858