Impact of age on locoregional and distant recurrence after mastectomy for ductal carcinoma in situ with or without microinvasion Journal Article
| Authors: | Mamtani, A.; Nakhlis, F.; Downs-Canner, S.; Zabor, E. C.; Morrow, M.; King, T. A.; Van Zee, K. J. |
| Article Title: | Impact of age on locoregional and distant recurrence after mastectomy for ductal carcinoma in situ with or without microinvasion |
| Abstract: | Background: Locoregional recurrence (LRR) after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) is increased in young women. We examined the impact of age on LRR and distant disease after mastectomy for DCIS ± microinvasion. Methods: We identified consecutive patients with DCIS ± microinvasion treated with mastectomy from 1995 to 2017. LRR was defined as recurrence at the ipsilateral chest wall or regional nodes. Results: Overall, 3121 cases were identified, of which 421 (13.5%) had DCIS + microinvasion. Median age was 49 years and median follow-up was 6.4 years; 821 were followed for 10 or more years. Thirty-four LRRs were observed: 33 (97%) were invasive, and 23 (68%) were in the chest wall alone. Cumulative 10-year LRR incidence was 1.4%. Age < 50 years, high grade, and DCIS + microinvasion were associated with LRR (p ≤ 0.001); however, margin status was not (p = 0.14). Adjusting for grade and DCIS + microinvasion, age < 50 years (hazard ratio [HR] 14.7, 95% confidence interval [CI] 3.5–61.5; p < 0.001) was associated with LRR. Compared with women ≥ 50 years of age, women age < 40 years had the highest risk (HR 27.0, 95% CI 6.0–121), and women age 40–49 years had intermediate risk (HR 11.8, 95% CI 2.8–50.5). The cumulative 10-year LRR incidence was 4.2% for women < 40 years of age, 2.0% for women 40–49 years of age, and 0.2% for women ≥ 50 years of age. Women age < 40 years had a 10-year distant disease rate of 1.6% versus women age 40–49 years (0.7%) and women age ≥ 50 years (0.7%) (log-rank p = 0.051). Grade, DCIS + microinvasion, and margins were unassociated with distant disease. Conclusions: LRR after mastectomy for DCIS ± microinvasion is uncommon, but is more frequent among women < 50 years of age, particularly in those < 40 years of age. The 10-year LRR rate in this youngest group remains low at 4.2%. Young age is an independent risk factor for LRR after BCS or mastectomy. © 2019, Society of Surgical Oncology. |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 26 |
| Issue: | 13 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2019-12-01 |
| Start Page: | 4264 |
| End Page: | 4271 |
| Language: | English |
| DOI: | 10.1245/s10434-019-07693-1 |
| PUBMED: | 31440931 |
| PROVIDER: | scopus |
| PMCID: | PMC6868329 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 December 2019 -- Source: Scopus |
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