Breast cancer in young black women Journal Article
| Authors: | Walsh, S. M.; Zabor, E. C.; Flynn, J.; Stempel, M.; Morrow, M.; Gemignani, M. L. |
| Article Title: | Breast cancer in young black women |
| Abstract: | Background: Young age at breast cancer diagnosis is associated with negative prognostic outcomes, and breast cancer in black women often manifests at a young age. This study evaluated the effect of age on breast cancer management and outcomes in black women. Methods: This was a retrospective cohort study of all black women treated for invasive breast cancer between 2005 and 2010 at a specialized tertiary-care cancer centre. Clinical and treatment characteristics were compared by age. Kaplan–Meier methodology was used to estimate overall survival (OS) and disease-free survival (DFS). Results: A total of 666 black women were identified. Median BMI was 30 (range 17–56) kg/m2 and median tumour size was 16 (1–155) mm. Most tumours were oestrogen receptor-positive (66·4 per cent). Women were stratified by age: less than 40 years (74, 11·1 per cent) versus 40 years or more (592, 88·9 per cent). Younger women were significantly more likely to have a mastectomy, axillary lymph node dissection and to receive chemotherapy, and were more likely to have lymphovascular invasion and positive lymph nodes, than older women. The 5-year OS rate was 88·0 (95 per cent c.i. 86·0 to 91·0) per cent and the 5-year DFS rate was 82·0 (79·0 to 85·0) per cent. There was no statistically significant difference in OS by age (P = 0·236). Although DFS was inferior in younger women on univariable analysis (71 versus 88 per cent; P < 0·001), no association was found with age on multivariable analysis. Conclusion: Young black women with breast cancer had more adverse pathological factors, received more aggressive treatment, and had worse DFS on univariable analysis. Young age at diagnosis was, however, not an independent predictor of outcome. © 2020 BJS Society Ltd Published by John Wiley & Sons Ltd |
| Keywords: | adult; cancer chemotherapy; controlled study; aged; major clinical study; overall survival; cancer recurrence; cancer risk; disease free survival; cancer staging; follow up; cancer diagnosis; lymph node dissection; breast cancer; mastectomy; tumor volume; epidermal growth factor receptor 2; cohort analysis; retrospective study; age; health insurance; body mass; mammography; estrogen receptor; progesterone receptor; clinical outcome; local recurrence free survival; human epidermal growth factor receptor 2 positive breast cancer; time to treatment; human; female; priority journal; article; black person; progesterone receptor positive breast cancer; distant recurrence free survival |
| Journal Title: | British Journal of Surgery |
| Volume: | 107 |
| Issue: | 6 |
| ISSN: | 0007-1323 |
| Publisher: | Oxford University Press |
| Date Published: | 2020-05-01 |
| Start Page: | 677 |
| End Page: | 686 |
| Language: | English |
| DOI: | 10.1002/bjs.11401 |
| PUBMED: | 31981221 |
| PROVIDER: | scopus |
| PMCID: | PMC7422000 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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