Novel insights into the early histopathogenesis of immunodeficiency-associated Burkitt lymphoma: A case report of Burkitt microlymphoma arising within HIV lymphadenitis Journal Article
| Authors: | Park, D.; Ozkaya, N.; Hariharan, A. |
| Article Title: | Novel insights into the early histopathogenesis of immunodeficiency-associated Burkitt lymphoma: A case report of Burkitt microlymphoma arising within HIV lymphadenitis |
| Abstract: | Aims: To report a case detailing the early histopathogenesis of Burkitt lymphoma (BL), Epstein-Barr virus (EBV) positive, in the clinical setting of HIV infection. Methods and results: We describe a 57 year-old woman with newly diagnosed HIV infection who presented with unilateral localized axillary lymphadenopathy. Histopathological, immunohistochemical, and flow cytometric analyses were performed and showed EBV-positive nests of Burkitt cells, including rare nests also positive for cytomegalovirus, exclusively located within hyperplastic monocytoid B-cell areas of HIV lymphadenitis. Due to positron emission tomography/computed tomography findings of persistent localized lymphadenopathy with markedly increased fludeoxyglucose avidity a core needle biopsy was performed. Histopathological, immunohistochemical, fluorescence in situ hybridization, and flow cytometric analyses confirmed BL. Conclusions: Early histopathogenesis of HIV-associated BL occurred as nests of EBV-positive Burkitt cells within prominent monocytoid B-cell areas in our case. The results equip the pathologist to identify a very subtle Burkitt microlymphoma which would allow for prompt and appropriate chemotherapeutic intervention and may promote research into the possible relationship between monocytoid B cells and BL. © 2016 John Wiley & Sons Ltd |
| Keywords: | human immunodeficiency virus; cytomegalovirus; burkitt lymphoma; epstein-barr virus; monocytoid |
| Journal Title: | Histopathology |
| Volume: | 69 |
| Issue: | 3 |
| ISSN: | 0309-0167 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2016-09-01 |
| Start Page: | 516 |
| End Page: | 521 |
| Language: | English |
| DOI: | 10.1111/his.12960 |
| PUBMED: | 26953628 |
| PROVIDER: | scopus |
| PMCID: | PMC5633933 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 September 2016 -- Source: Scopus |
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