Transformation of monoclonal b lymphocytosis to Epstein-Barr virus-positive large B-cell lymphoma with intermediate features between diffuse large B-cell lymphoma and classic Hodgkin lymphoma Journal Article


Authors: Liu, Y.; Ho, C.; Roshal, M.; Baik, J.; Arcila, M.; Zhang, Y.; Dogan, A.; Xiao, W.
Article Title: Transformation of monoclonal b lymphocytosis to Epstein-Barr virus-positive large B-cell lymphoma with intermediate features between diffuse large B-cell lymphoma and classic Hodgkin lymphoma
Abstract: Transformation of chronic lymphocytic leukemia (CLL) to an aggressive lymphoma, so-called Richter syndrome, usually includes diffuse large B-cell lymphoma and classic Hodgkin lymphoma. The transformation can be clonally related to the underlying CLL and is often Epstein-Barr virus (EBV) associated. Here we report the case of an 86-year-old woman with a newly identified CLL-like monoclonal B-lymphocytosis who developed diffuse lymphadenopathy. Biopsy of the left axillary lymph node showed EBV-positive large B-cell lymphoma with morphologic and immunophenotypic features intermediate between diffuse large B-cell lymphoma and classic Hodgkin lymphoma, so-called gray zone lymphoma. Comprehensive immunophenotypic, cytogenetic, and molecular studies demonstrate a clonal relatedness that suggests a transformation from monoclonal B-lymphocytosis to EBV+ gray zone lymphoma.
Keywords: leukemia; disease; variant; clonality; origin; chronic lymphocytic leukemia; gray zone lymphoma; sternberg cells; mutational status; classic hodgkin lymphoma; epstein-barr; zone lymphoma; virus(+) diffuse large b-cell lymphoma; monoclonal b-lymphocytosis; richter syndrome/transformation; richters-syndrome; represent
Journal Title: AJSP: Reviews and Reports
Volume: 24
Issue: 5
ISSN: 2381-5949
Publisher: Lippincott Williams & Wilkins  
Date Published: 2019-09-01
Start Page: 207
End Page: 211
Language: English
ACCESSION: WOS:000489706600005
DOI: 10.1097/pcr.0000000000000326
PROVIDER: wos
PMCID: PMC7799843
PUBMED: 33437870
Notes: Review -- Source: Wos
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MSK Authors
  1. Maria Eugenia Arcila
    666 Arcila
  2. Ahmet Dogan
    456 Dogan
  3. Mikhail Roshal
    232 Roshal
  4. Caleb   Ho
    73 Ho
  5. Yanming Zhang
    199 Zhang
  6. Wenbin Xiao
    109 Xiao
  7. Jee Yeon Baik
    44 Baik
  8. Ying Liu
    33 Liu