Transformation of monoclonal b lymphocytosis to Epstein-Barr virus-positive large B-cell lymphoma with intermediate features between diffuse large B-cell lymphoma and classic Hodgkin lymphoma Journal Article
| Authors: | Liu, Y.; Ho, C.; Roshal, M.; Baik, J.; Arcila, M.; Zhang, Y.; Dogan, A.; Xiao, W. |
| Article Title: | Transformation of monoclonal b lymphocytosis to Epstein-Barr virus-positive large B-cell lymphoma with intermediate features between diffuse large B-cell lymphoma and classic Hodgkin lymphoma |
| Abstract: | Transformation of chronic lymphocytic leukemia (CLL) to an aggressive lymphoma, so-called Richter syndrome, usually includes diffuse large B-cell lymphoma and classic Hodgkin lymphoma. The transformation can be clonally related to the underlying CLL and is often Epstein-Barr virus (EBV) associated. Here we report the case of an 86-year-old woman with a newly identified CLL-like monoclonal B-lymphocytosis who developed diffuse lymphadenopathy. Biopsy of the left axillary lymph node showed EBV-positive large B-cell lymphoma with morphologic and immunophenotypic features intermediate between diffuse large B-cell lymphoma and classic Hodgkin lymphoma, so-called gray zone lymphoma. Comprehensive immunophenotypic, cytogenetic, and molecular studies demonstrate a clonal relatedness that suggests a transformation from monoclonal B-lymphocytosis to EBV+ gray zone lymphoma. |
| Keywords: | leukemia; disease; variant; clonality; origin; chronic lymphocytic leukemia; gray zone lymphoma; sternberg cells; mutational status; classic hodgkin lymphoma; epstein-barr; zone lymphoma; virus(+) diffuse large b-cell lymphoma; monoclonal b-lymphocytosis; richter syndrome/transformation; richters-syndrome; represent |
| Journal Title: | AJSP: Reviews and Reports |
| Volume: | 24 |
| Issue: | 5 |
| ISSN: | 2381-5949 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2019-09-01 |
| Start Page: | 207 |
| End Page: | 211 |
| Language: | English |
| ACCESSION: | WOS:000489706600005 |
| DOI: | 10.1097/pcr.0000000000000326 |
| PROVIDER: | wos |
| PMCID: | PMC7799843 |
| PUBMED: | 33437870 |
| Notes: | Review -- Source: Wos |
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