Esophageal cancer phospholipids correlated with histopathologic findings: A (31)P NMR study Journal Article

  

Authors:	Merchant, T. E.; Minsky, B. D.; Lauwers, G. Y.; Diamantis, P. M.; Haida, T.; Glonek, T.
Article Title:	Esophageal cancer phospholipids correlated with histopathologic findings: A (31)P NMR study
Abstract:	We analyzed 36 esophageal tumor specimens for phospholipid content using phosphorus nuclear magnetic resonance spectroscopy (31P NMR) and correlated the individual phospholipid profiles with specific clinical and histopathologic features. Among the 18 phospholipids identified in the esophageal tumor specimens, the mean mole percentage concentration of dimethylphosphatidylethanolamine, lysoalkylacylphosphatidylcholine, lysophosphatidic acid, lysophosphatidylcholine (deacylated at the glycerol-1 carbon), and lysoethanolamine plasmalogen correlated with pathologic T stage, nuclear grade, or the presence of lymphatic invasion. 31P NMR produces well-dispersed phospholipid spectra and a precise determination of phospholipid relative mole percentages. These data provide a statistical correlation between histopathologic features and molecules known to play an important role in cellular activities and processes unique to malignant tissues.
Keywords:	human tissue; unclassified drug; histopathology; cancer staging; cancer grading; neoplasms; cancer invasion; lymphatic system; magnetic resonance spectroscopy; esophagus cancer; phosphorus nuclear magnetic resonance; esophagus; esophageal neoplasms; phospholipids; phosphorus 31; phospholipid; lipid composition; nmr; lysophosphatidylcholine; correlation function; lysophosphatidic acid; cancer; humans; human; priority journal; article; plasmalogen; 31p nmr; lysoethanolamine; n,n dimethylphosphatidylethanolamine
Journal Title:	NMR in Biomedicine
Volume:	12
Issue:	4
ISSN:	0952-3480
Publisher:	John Wiley & Sons
Date Published:	1999-06-01
Start Page:	184
End Page:	188
Language:	English
DOI:	10.1002/(sici)1099-1492(199906)12:4<184::aid-nbm560>3.0.co;2-m
PUBMED:	10421909
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032811433&partnerID=40&md5=d3e7db968667fdcd2fcd5fb9a6f85584
Notes:	Article -- Export Date: 16 August 2016 -- Source: Scopus

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