Malignant breast tumor phospholipid profiles using (31)P magnetic resonance Journal Article
| Authors: | Merchant, T. E.; Kasimos, J. N.; Vroom, T.; de Bree, E.; Iwata, J. L.; de Graaf, P. W.; Glonek, T. |
| Article Title: | Malignant breast tumor phospholipid profiles using (31)P magnetic resonance |
| Abstract: | Biochemical markers improve the classification and staging of breast cancer and may refine management decisions if it can be shown that they correlate with accepted prognostic factors or patient outcome. Using phosphorus-31 magnetic resonance spectroscopy (31P MRS), we determined the phospholipid content of 43 malignant breast tumors, correlating the profiles with specific histopathologic and clinical features and hormone receptor status. Among the 14 phospholipids identified, the mean mole percentage of sphingomyelin, phosphatidylcholine, phosphatidylserine, phosphatidic acid, phosphatidylglycerol, and alkylacylphosphatidylcholine predicted cellular infiltration, infiltration type, elastosis, lymphatic invasion, perineural invasion, necrosis, and estrogen receptor positivity. 31P MRS phospholipid profile data provide statistical correlations among histologic features and molecules known to play important roles in cellular communication, regulation, and processes unique to malignant tissues. © 2002 Elsevier Science Ireland Ltd. All rights reserved. |
| Keywords: | controlled study; human tissue; unclassified drug; clinical feature; histopathology; treatment planning; cancer staging; magnetic resonance imaging; lymphatic metastasis; neoplasm staging; cell infiltration; breast neoplasms; necrosis; cancer invasion; breast tumor; data analysis; magnetic resonance spectroscopy; nuclear magnetic resonance spectroscopy; receptors, estrogen; multivariate analysis; phosphatidylethanolamine; cancer classification; hormone receptor; decision making; cell communication; protein determination; phosphatidic acid; phosphatidylcholine; phospholipids; phosphorus 31; phospholipid; sphingomyelin; elastosis; phosphatidylserine; lysophosphatidylcholine; granulocytes; phosphatidylinositol; phosphatidylcholines; biochemical marker; sphingomyelins; protein content; phosphorus radioisotopes; phosphatidylserines; phosphatidic acids; humans; prognosis; human; priority journal; article; ethanolamine derivative; cardiolipin; dihydrosphingomyelin; lysophosphatidylethanolamine; phosphatidylglycerol; plasmalogen; sphingosylphosphorylcholine; phosphatidylglycerols |
| Journal Title: | Cancer Letters |
| Volume: | 176 |
| Issue: | 2 |
| ISSN: | 0304-3835 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 2002-02-25 |
| Start Page: | 159 |
| End Page: | 167 |
| Language: | English |
| DOI: | 10.1016/s0304-3835(01)00780-7 |
| PUBMED: | 11804743 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
