A fully synthetic globo H carbohydrate vaccine induces a focused humoral response in prostate cancer patients: A proof of principle Journal Article
| Authors: | Ragupathi, G.; Slovin, S. F.; Adluri, S.; Sames, D.; Kim, I. J.; Kim, H. M.; Spassova, M.; Bornmann, W. G.; Lloyd, K. O.; Scher, H. I.; Livingston, P. O.; Danishefsky, S. J. |
| Article Title: | A fully synthetic globo H carbohydrate vaccine induces a focused humoral response in prostate cancer patients: A proof of principle |
| Abstract: | Human trials on the globo H carbohydrate vaccine (see picture, KLH = the carrier protein keyhole limpet hemocyanin) show that it produces strong IgM, and in some cases IgG, responses in patients with progressive and recurrent prostate cancer. Furthermore, these antibodies not only recognize synthetic antigens, but also globo H-positive tumors in biopsy extracts and tumor tissues. |
| Keywords: | clinical article; treatment indication; cancer immunotherapy; melanoma; breast cancer; cytotoxicity; drug structure; tumor antigen; prostate cancer; drug research; immune response; cancer vaccine; vaccination; vaccine production; humoral immunity; carbohydrates; antitumor agents; vaccines; glycoconjugates; globo h; human; male; article |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 38 |
| Issue: | 4 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1999-02-15 |
| Start Page: | 563 |
| End Page: | 566 |
| Language: | English |
| PROVIDER: | scopus |
| DOI: | 10.1002/(SICI)1521-3773(19990215)38:4<563::AID-ANIE563>3.0.CO;2-3 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work