The LRF transcription factor regulates mature B cell development and the germinal center response in mice Journal Article
| Authors: | Sakurai, N.; Maeda, M.; Lee, S. U.; Ishikawa, Y.; Li, M.; Williams, J. C.; Wang, L.; Su, L.; Suzuki, M.; Saito, T. I.; Chiba, S.; Casola, S.; Yagita, H.; Teruya-Feldstein, J.; Tsuzuki, S.; Bhatia, R.; Maeda, T. |
| Article Title: | The LRF transcription factor regulates mature B cell development and the germinal center response in mice |
| Abstract: | B cells play a central role in immune system function. Deregulation of normal B cell maturation can lead to the development of autoimmune syndromes as well as B cell malignancies. Elucidation of the molecular features of normal B cell development is important for the development of new target therapies for autoimmune diseases and B cell malignancies. Employing B cell-specific conditional knockout mice, we have demonstrated here that the transcription factor leukemia/lymphoma-related factor (LRF) forms an obligate dimer in B cells and regulates mature B cell lineage fate and humoral immune responses via distinctive mechanisms. Moreover, LRF inactivation in transformed B cells attenuated their growth rate. These studies identify what we believe to be a new key factor for mature B cell development and provide a rationale for targeting LRF dimers for the treatment of autoimmune diseases and B cell malignancies. |
| Keywords: | controlled study; unclassified drug; nonhuman; protein function; lymphocyte proliferation; animal cell; mouse; cell survival; cell growth; cell maturation; animal experiment; transcription factor; cell fate; b lymphocyte; cell lineage; b cell lymphoma; germinal center; nucleotide sequence; upregulation; humoral immunity; lymphocyte function; dimer; leukemia lymphoma related factor; lymphoma cell line |
| Journal Title: | Journal of Clinical Investigation |
| Volume: | 121 |
| Issue: | 7 |
| ISSN: | 0021-9738 |
| Publisher: | American Society for Clinical Investigation |
| Date Published: | 2011-07-01 |
| Start Page: | 2583 |
| End Page: | 2598 |
| Language: | English |
| DOI: | 10.1172/jci45682 |
| PROVIDER: | scopus |
| PUBMED: | 21646720 |
| PMCID: | PMC3223838 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 17 August 2011" - "CODEN: JCINA" - "Source: Scopus" |
