Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF Journal Article


Authors: Maeda, T.; Merghoub, T.; Hobbs, R. M.; Dong, L.; Maeda, M.; Zakrzewski, J.; van den Brink, M. R. M.; Zelent, A.; Shigematsu, H.; Akashi, K.; Teruya-Feldstein, J.; Cattoretti, G.; Pandolfi, P. P.
Article Title: Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF
Abstract: Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop info B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.
Keywords: signal transduction; unclassified drug; dna binding protein; gene deletion; genetics; dna-binding proteins; nonhuman; t lymphocyte; t-lymphocytes; animal cell; mouse; animal; cytology; metabolism; mouse mutant; animals; mice; mice, knockout; bone marrow cells; cells, cultured; gene targeting; mus; proto oncogene; immune system; biological model; models, biological; cell maturation; protein; notch receptor; transcription factor; cell fate; mice, inbred c57bl; physiology; b lymphocyte; cell lineage; c57bl mouse; b-lymphocytes; transcription factors; stem cell; cell culture; thymus; thymus gland; receptors, notch; bone; hematopoietic stem cells; bone marrow cell; hematopoietic stem cell; lymphopoiesis; proto-oncogenes; zbtb7a protein, mouse
Journal Title: Science
Volume: 316
Issue: 5826
ISSN: 0036-8075
Publisher: American Association for the Advancement of Science  
Date Published: 2007-05-11
Start Page: 860
End Page: 866
Language: English
DOI: 10.1126/science.1140881
PUBMED: 17495164
PROVIDER: scopus
PMCID: PMC2978506
DOI/URL:
Notes: --- - "Cited By (since 1996): 71" - "Export Date: 17 November 2011" - "CODEN: SCIEA" - "Source: Scopus"
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