31P MR spectroscopic imaging detects regenerative changes in human liver stimulated by portal vein embolization Journal Article

   


Authors: Qi, J.; Shukla-Dave, A.; Fong, Y.; Gonen, M.; Schwartz, L. H.; Jarnagin, W. R.; Koutcher, J. A.; Zakian, K. L.
Article Title: 31P MR spectroscopic imaging detects regenerative changes in human liver stimulated by portal vein embolization
Abstract: Purpose: First, to evaluate hepatocyte phospholipid metabolism and energetics during liver regeneration stimulated by portal vein embolization (PVE) using proton-decoupled 31P MR spectroscopic imaging ( 31P-MRSI). Second, to compare the biophysiologic differences between hepatic regeneration stimulated by PVE and by partial hepatectomy (PH). Materials and Methods: Subjects included six patients with hepatic metastases from colorectal cancer who were scheduled to undergo right PVE before definitive resection of right-sided tumor.31P-MRSI was performed on the left liver lobe before PVE and 48 h following PVE. Normalized quantities of phosphorus-containing hepatic metabolites were analyzed from both visits. In addition, MRSI data at 48 h following partial hepatectomy were compared with the data from the PVE patients. Results: At 48 h after PVE, the ratio of phosphomonoesters to phosphodiesters in the nonembolized lobe was significantly elevated. No significant changes were found in nucleoside triphosphates (NTP) and Pi values. The phosphomonoester (PME) to phosphodiester (PDE) ratio in regenerating liver 48 h after partial hepatectomy was significantly greater than PME/PDE 48 h after PVE. Conclusion: 31P-MRSI is a valid technique to noninvasively evaluate cell membrane metabolism following PVE. The different degree of biochemical change between partial hepatectomy and PVE indicates that hepatic growth following these two procedures does not follow the same course. © 2011 Wiley-Liss, Inc.
Keywords: adult; cancer chemotherapy; clinical article; controlled study; aged; aged, 80 and over; middle aged; bevacizumab; fluorouracil; artificial embolism; treatment duration; liver neoplasms; follow up; methodology; colorectal cancer; metabolism; hepatocytes; phosphatase; pathology; diagnostic imaging; time; time factors; irinotecan; alanine aminotransferase blood level; aspartate aminotransferase blood level; regeneration; alanine aminotransferase; alkaline phosphatase; aspartate aminotransferase; bilirubin; liver metastasis; liver; diagnostic value; folinic acid; liver tumor; cell membrane; magnetic resonance spectroscopy; nuclear magnetic resonance spectroscopy; liver resection; hepatectomy; protons; alkaline phosphatase blood level; liver cell; liver regeneration; oxaliplatin; floxuridine; phosphorus nuclear magnetic resonance; bilirubin blood level; spectroscopy; portal vein; embolization, therapeutic; partial hepatectomy; proton; phosphorus 31; phosphorus; phosphorus isotopes; comparative effectiveness; nucleoside triphosphate; phospholipid metabolism; phosphodiesterase; portal vein embolization; spectrophotometry
Journal Title: Journal of Magnetic Resonance Imaging
Volume: 34
Issue: 2
ISSN: 1053-1807
Publisher: Wiley Blackwell  
Date Published: 2011-08-01
Start Page: 336
End Page: 344
Language: English
DOI: 10.1002/jmri.22616
PROVIDER: scopus
PMCID: PMC3146030
PUBMED: 21780228
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-79960579090&partnerID=40&md5=f01f7cd11d558e5de1b18c2b3c1e74b4
Notes: --- - "Export Date: 17 August 2011" - "CODEN: JMRIF" - "Source: Scopus"
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MSK Authors
  1. Mithat Gonen
    1028 Gonen
  2. William R Jarnagin
    903 Jarnagin
  3. Yuman Fong
    775 Fong
  4. Amita Dave
    137 Dave
  5. Kristen L Zakian
    82 Zakian
  6. Jason A Koutcher
    278 Koutcher
  7. Jing Qi
    2 Qi
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