Liver regeneration in humans is characterized by significant changes in cellular phosphorus metabolism: Assessment using proton-decoupled 31P-magnetic resonance spectroscopic imaging Journal Article

  

Authors:	Zakian, K. L.; Koutcher, J. A.; Malhotra, S.; Thaler, H.; Jarnagin, W.; Schwartz, L.; Fong, Y.
Article Title:	Liver regeneration in humans is characterized by significant changes in cellular phosphorus metabolism: Assessment using proton-decoupled 31P-magnetic resonance spectroscopic imaging
Abstract:	In the present study we applied proton-decoupled 31P magnetic resonance spectroscopic imaging (MRSI) to noninvasively assess liver metabolism in patients who had undergone a partial hepatectomy (PH). Proton-decoupled 31P chemical shift imaging was performed in 47 patients 2-28 days following major hepatectomy, and the results were compared with those from eight control subjects. All studies were performed on a 1.5T MR imager (General Electric, Milwaukee, WI) equipped with a stand-alone proton decoupler. A 31P-1H resonator pair was used for data acquisition, and 31P data were obtained in 34 min. Liver regeneration was characterized by increases in phosphoethanolamine (PE), and decreases in nucleoside triphosphates (NTP), glycerophosphoethanolamine (GPE), and glycerophosphocholine (GPC). These alterations were most marked 48-72 hr after hepatectomy and returned to baseline within 3 weeks. The level of PE measured by MRSI was also found to depend on the percentage of liver that was removed, while changes in levels of cellular high energy phosphates were independent of the size of liver resection. Implementation of proton-decoupling was critical for assessing individual phosphomonoester and phosphodiester components. This study demonstrates that 31P MRSI can be used to assess metabolic changes in humans during liver regeneration, and may be useful for assessing derangement of the regenerative process or guiding adjuvant chemotherapies. © 2005 Wiley-Liss, Inc.
Keywords:	adult; clinical article; controlled study; aged; cancer adjuvant therapy; metabolism; regeneration; liver metastasis; liver; liver tumor; magnetic resonance spectroscopy; liver resection; hepatectomy; liver cancer; liver regeneration; phosphorus nuclear magnetic resonance; spectroscopy; statistics, nonparametric; partial hepatectomy; phosphoethanolamine; phosphorus; phosphorus isotopes; liver function tests; nucleoside triphosphate; glycerophosphoethanolamine; glycerophosphorylcholine; high energy phosphate; liver metabolism; phosphate metabolism
Journal Title:	Magnetic Resonance in Medicine
Volume:	54
Issue:	2
ISSN:	0740-3194
Publisher:	John Wiley & Sons
Date Published:	2005-08-01
Start Page:	264
End Page:	271
Language:	English
DOI:	10.1002/mrm.20560
PUBMED:	16032692
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-22744434731&partnerID=40&md5=5d4e98b1b3b2cf45134db64629f9067c
Notes:	--- - "Cited By (since 1996): 6" - "Export Date: 24 October 2012" - "CODEN: MRMEE" - "Source: Scopus"

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