Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck Journal Article
| Authors: | Veit, J. A.; Heine, D.; Thierauf, J.; Lennerz, J.; Shetty, S.; Schuler, P. J.; Whiteside, T.; Beutner, D.; Meyer, M.; Grünewald, I.; Ritter, G.; Gnjatic, S.; Sikora, A. G.; Hoffmann, T. K.; Laban, S. |
| Article Title: | Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck |
| Abstract: | Background Adenoid cystic carcinoma (ACC) of the head and neck is a rare but highly malignant tumor. Cancer-testis antigens (CTAs) represent an immunogenic family of cancer-specific proteins and thus represent an attractive target for immunotherapy. Methods Eighty-four cases of ACC were identified, the CTAs pan-Melanoma antigen (pan-MAGE; M3H67) and New York esophageal squamous cell carcinoma (NY-ESO-1; E978) were detected immunohistochemically (IHC) and correlated with clinical data. Results Expression of NY-ESO-1 was found in 48 of 84 patients (57.1%) and of pan-MAGE in 28 of 84 patients (31.2%). Median overall survival (OS) in NY-ESO-1 positive versus negative patients was 130.8 and 282.0 months (p =.223), respectively. OS in pan-MAGE positive versus negative patients was 105.3 and 190.5 months, respectively (p =.096). Patients expressing both NY-ESO-1 and pan-MAGE simultaneously had significantly reduced OS with a median of 90.5 months compared with 282.0 months in negative patients (p =.047). Conclusion A significant fraction of patients with ACC show expression of the CTAs NY-ESO-1 and/or pan-MAGE with promising immunotherapeutic implications. © 2016 Wiley Periodicals, Inc. |
| Keywords: | head and neck cancer; melanoma antigen; adenoid cystic carcinoma; cancer-testis antigens; new york esophageal squamous cell carcinoma (ny-eso-1) |
| Journal Title: | Head & Neck |
| Volume: | 38 |
| Issue: | 7 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2016-07-01 |
| Start Page: | 1008 |
| End Page: | 1016 |
| Language: | English |
| DOI: | 10.1002/hed.24403 |
| PROVIDER: | scopus |
| PUBMED: | 26874246 |
| PMCID: | PMC5557286 |
| DOI/URL: | |
| Notes: | Conference Paper: This work was presented at the annual meeting of the American Head and Neck Society (AHNS) in New York, NY that took place July 26–30, 2014, and part of the work was presented at the annual DGHNO meeting in Dortmund, Germany that took place May 28 to June 1, 2014. -- Export Date: 1 July 2016 -- Source: Scopus |
