Cancer-testis antigens: Expression and correlation with survival in human urothelial carcinoma Journal Article
| Authors: | Sharma, P.; Shen, Y.; Wen, S.; Bajorin, D. F.; Reuter, V. E.; Old, L. J.; Jungbluth, A. A. |
| Article Title: | Cancer-testis antigens: Expression and correlation with survival in human urothelial carcinoma |
| Abstract: | Purpose: Vaccination against human cancer is a promising therapeutic approach but the optimal antigen or antigens remain undefined. Cancer-testis antigens (CTA), a family of tumor-associated antigens, have both potent immunogenicity and restricted expression patterns in normal adult tissues, highly desirable characteristics for targets of anticancer vaccines. These antigens were evaluated for both the degree of expression and prognostic value in cancer of the urothelium. Experimental Design: The expression patterns of nine CTAs (NY-ESO-1, LAGE-1, MAGE-A1, MAGE-A3, MAGE-A4, MAGE-A10, CT7, CT10, and GAGE) were examined by immunohistochemistry and reverse transcription-PCR in a panel of high-grade urothelial carcinomas of the urinary bladder. Also assessed were correlations between the expression of CTAs by immunohistochemistry and both disease-free and overall survival. Results: At least one CTA was expressed in 77% of samples and 61% of these tumors expressed more than one CTA. Additionally, patients with CT10-positive tumors had an improved disease-free survival (P = 0.008) and overall survival (P = 0.037) compared with patients with CT10-negative tumors. Conclusions: These findings establish CTAs as potential prognostic markers and as target candidates for vaccine development for patients with urothelial carcinoma. © 2006 American Association for Cancer Research. |
| Keywords: | immunohistochemistry; cancer survival; controlled study; human tissue; survival analysis; retrospective studies; unclassified drug; major clinical study; histopathology; drug targeting; disease free survival; cancer grading; antigen expression; cancer immunotherapy; reverse transcription polymerase chain reaction; statistics; urogenital tract cancer; urologic neoplasms; antigens, neoplasm; cancer testis antigen; melanoma antigen 1; melanoma antigen 10; melanoma antigen 3; ny eso 1 antigen; immunogenicity; statistics as topic; carcinoma; testicular neoplasms; bladder carcinoma; transitional cell carcinoma; testis; gage antigen; melanoma antigen 4; ct10 antigen; ct7 antigen; lage 1 antigen |
| Journal Title: | Clinical Cancer Research |
| Volume: | 12 |
| Issue: | 18 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2006-09-15 |
| Start Page: | 5442 |
| End Page: | 5447 |
| Language: | English |
| DOI: | 10.1158/1078-0432.ccr-06-0527 |
| PUBMED: | 17000678 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 20" - "Export Date: 4 June 2012" - "CODEN: CCREF" - "Source: Scopus" |
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