Expression of cancer-testis antigens MAGE-A4 and MAGE-C1 in oral squamous cell carcinoma Journal Article
| Authors: | Montoro, J. R. D. M. C.; Mamede, R. C. M.; Neder Serafini, L.; Saggioro, F. P.; Figueiredo, D. L. A.; Silva, W. A. D.; Jungbluth, A. A.; Spagnoli, G. C.; Zago, M. A. |
| Article Title: | Expression of cancer-testis antigens MAGE-A4 and MAGE-C1 in oral squamous cell carcinoma |
| Abstract: | Background Tumor markers are genes or their products expressed exclusively or preferentially in tumor cells and cancer-testis antigens (CTAs) form a group of genes with a typical expression pattern expressed in a variety of malignant neoplasms. CTAs are considered potential targets for cancer vaccines. It is possible that the CTA MAGE-A4 (melanoma antigen) and MAGE-C1 are expressed in carcinoma of the oral cavity and are related with survival. Methods This study involved immunohistochemical analysis of 23 patients with oral squamous cell carcinoma (SCC) and was carried out using antibodies for MAGE-A4 and MAGE-C1. Fisher's exact test and log-rank test were used to evaluate the results. Results The expression of the MAGE-A4 and MAGE-C1 were 56.5% and 47.8% without statistical difference in studied variables and survival. Conclusion The expression of at least 1 CTA was present in 78.3% of the patients, however, without correlation with clinicopathologic variables and survival. © 2011 Wiley Periodicals, Inc. Head Neck, 2012 Copyright © 2011 Wiley Periodicals, Inc. |
| Keywords: | immunohistochemistry; adult; cancer survival; clinical article; controlled study; human tissue; aged; middle aged; survival rate; unclassified drug; overall survival; carcinoma, squamous cell; antigen expression; demography; neoplasm proteins; tumor markers, biological; smoking; survival time; antigens, neoplasm; cancer testis antigen; melanoma antigen c1; mouth neoplasms; alcohol drinking; melanoma antigen 4; cancer antibody; biological tumor markers; mage-a4; mage-c1; mouth squamous cell carcinoma |
| Journal Title: | Head & Neck |
| Volume: | 34 |
| Issue: | 8 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2012-08-01 |
| Start Page: | 1123 |
| End Page: | 1128 |
| Language: | English |
| DOI: | 10.1002/hed.21880 |
| PROVIDER: | scopus |
| PUBMED: | 22083937 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 September 2012" - "CODEN: HEANE" - "Source: Scopus" |
