Expression and significance of cancer testis antigens in primary mucosal melanoma of the head and neck Journal Article
| Authors: | Prasad, M. L.; Jungbluth, A. A.; Patel, S. G.; Iversen, K.; Hoshaw-Woodard, S.; Busam, K. J. |
| Article Title: | Expression and significance of cancer testis antigens in primary mucosal melanoma of the head and neck |
| Abstract: | Background. Cancer testis antigens (CTAs) are T-cell-defined tumor-associated antigens encoded by the genes and gene families such as MAGE, NY-ESO-1, and others. Their expression in a wide variety of malignant neoplasms but absence in all normal adult tissue except testicular germ cells makes them attractive targets for immunotherapy of cancer. Primary mucosal melanomas of the head and neck (HNMM) are rare aggressive malignant tumors that are usually difficult to treat. CTAs may provide useful targets for therapy; however, their expression in HNMM is not known. Methods. We analyzed 40 initial, 15 recurrent, and 15 metastatic HNMM to nonmucosal locations from 64 patients (oral, n = 30; sinonasal, n = 34). Immunohistochemistry was performed on archival tissue with monoclonal antibodies 57B, CT7-33, and ES121 to the following CTAs: MAGE-A4, CT7 (MAGE-C1), and NY-ESO-1, respectively. Results. CT7, MAGE-A4, and NY-ESO-1 expression was seen in 73%, 61%, and 24% of tumors, respectively, with 81% of the tumors expressing at least one of the CTAs. CT7 and MAGE-A4 were significantly more frequently expressed in tumors composed of epithelioid cells than spindle cells (p = .05). CTA expression did not correlate with disease progression, overall survival, and disease-specific survival. Conclusions. CT7, MAGEA4, and NY-ESO-1 are frequently expressed in HNMM and may be potential targets for CTA-based immune-therapy. The expression does not seem to have prognostic significance. © 2004 Wiley Periodicals, Inc. |
| Keywords: | immunohistochemistry; controlled study; human tissue; aged; aged, 80 and over; middle aged; survival analysis; retrospective studies; unclassified drug; major clinical study; follow-up studies; sensitivity and specificity; antigen expression; melanoma; cohort studies; neoplasm recurrence, local; neoplasm proteins; tumor markers, biological; membrane proteins; monoclonal antibody; gene expression regulation, neoplastic; antigens, neoplasm; head and neck cancer; head and neck neoplasms; probability; disease progression; cancer testis antigen; melanoma antigen 1; ny eso 1 antigen; spindle cell; melanoma antigen a4; mouth mucosa; epithelioid cell; mage; mucosal melanoma; monoclonal antibody 57b; monoclonal antibody ct7 33; monoclonal antibody es121; humans; prognosis; human; male; female; priority journal; article |
| Journal Title: | Head & Neck |
| Volume: | 26 |
| Issue: | 12 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2004-12-01 |
| Start Page: | 1053 |
| End Page: | 1057 |
| Language: | English |
| DOI: | 10.1002/hed.20112 |
| PROVIDER: | scopus |
| PUBMED: | 15515159 |
| DOI/URL: | |
| Notes: | Export Date: 16 June 2014 -- Source: Scopus |
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