Expression of mage-A4 and mage-C1 tumor-associated antigen in benign and malignant thyroid diseases Journal Article
| Authors: | Melo, D. H.; Mamede, R. C. M.; Neder, L.; Saggioro, F. P.; Figueiredo, D. L. A.; Araújo Da Silva, W. Jr; Jungbluth, A. A.; Zago, M. A. |
| Article Title: | Expression of mage-A4 and mage-C1 tumor-associated antigen in benign and malignant thyroid diseases |
| Abstract: | Background A subset of thyroid tumors characterized by a follicular growth pattern can represent a serious diagnosis. Immunohistochemistry and molecular pathology for genetic profiling have been used in an attempt to resolve some of these issues. Methods Tumor tissue samples of thyroid were obtained from 70 patients who underwent surgical therapy. They were divided into 4 groups: 20 adenomatous goiters, 10 follicular adenomas, 24 papillary carcinomas, and 16 follicular carcinomas. Immunohistochemical analysis was carried out using antibodies for MAGE-A4 (melanoma antigen-encoding gene A4) and MAGE-C1 (melanoma antigen-encoding gene C1). Results Standard histologic analysis and immunohistochemistry analysis of MAGE-A4 and MAGE-C1 expression were performed in all patients. The antigens examined were not expressed in any of the tissues. Conclusions The malignant degeneration of normal tissues is a multifactorial process, varying considerably both among tumor types and among individual patients. The present study showed that there was no immunolabeling of the MAGE-A4 and MAGE-C1 antigens. © 2011 Wiley Periodicals, Inc. |
| Keywords: | immunohistochemistry; adolescent; adult; clinical article; controlled study; human tissue; protein expression; middle aged; unclassified drug; histopathology; differential diagnosis; carcinoma, papillary; neoplasm proteins; tumor antigen; adenoma; antigens, neoplasm; thyroid cancer; thyroid neoplasms; thyroid diseases; thyroid papillary carcinoma; adenocarcinoma, follicular; melanoma antigen 4; follicular carcinoma; biological tumor markers; mage-a4; mage-c1; thyroid disease; goiter; melanoma antigen c1 protein |
| Journal Title: | Head & Neck |
| Volume: | 33 |
| Issue: | 10 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2011-10-01 |
| Start Page: | 1426 |
| End Page: | 1432 |
| Language: | English |
| DOI: | 10.1002/hed.21616 |
| PROVIDER: | scopus |
| PUBMED: | 21246638 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 October 2011" - "CODEN: HEANE" - "Source: Scopus" |
