Innate lymphocyte/Ly6C(hi) monocyte crosstalk promotes Klebsiella pneumoniae clearance Journal Article
| Authors: | Xiong, H.; Keith, J. W.; Samilo, D. W.; Carter, R. A.; Leiner, I. M.; Pamer, E. G. |
| Article Title: | Innate lymphocyte/Ly6C(hi) monocyte crosstalk promotes Klebsiella pneumoniae clearance |
| Abstract: | Increasing antibiotic resistance among bacterial pathogens has rendered some infections untreatable with available antibiotics. Klebsiella pneumoniae, a bacterial pathogen that has acquired high-level antibiotic resistance, is a common cause of pulmonary infections. Optimal clearance of K. pneumoniae from the host lung requires TNF and IL-17A. Herein, we demonstrate that inflammatory monocytes are rapidly recruited to the lungs of K. pneumoniae-infected mice and produce TNF, which markedly increases the frequency of IL-17-producing innate lymphoid cells. While pulmonary clearance of K. pneumoniae is preserved in neutrophil-depleted mice, monocyte depletion or TNF deficiency impairs IL-17A-dependent resolution of pneumonia. Monocyte- mediated bacterial uptake and killing is enhanced by ILC production of IL-17A, indicating that innate lymphocytes engage in a positive-feedback loop with monocytes that promotes clearance of pneumonia. Innate immune defense against a highly antibiotic-resistant bacterial pathogen depends on crosstalk between inflammatory monocytes and innate lymphocytes that is mediated by TNF and IL-17A. |
| Keywords: | tumor-necrosis-factor; host-defense; th17 cells; immune; defense; rheumatoid-arthritis; liver-abscess; lymphoid-cells; protective role; ccr2(+) monocytes; il-17 |
| Journal Title: | Cell |
| Volume: | 165 |
| Issue: | 3 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2016-04-21 |
| Start Page: | 679 |
| End Page: | 689 |
| Language: | English |
| ACCESSION: | WOS:000374636800025 |
| DOI: | 10.1016/j.cell.2016.03.017 |
| PROVIDER: | wos |
| PMCID: | PMC4842125 |
| PUBMED: | 27040495 |
| Notes: | Article -- Source: Wos |
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