BrachyView: Multiple seed position reconstruction and comparison with CT post-implant dosimetry Journal Article
| Authors: | Alnaghy, S.; Loo, K. J.; Cutajar, D. L.; Jalayer, M.; Tenconi, C.; Favoino, M.; Rietti, R.; Tartaglia, M.; Carriero, F.; Safavi-Naeini, M.; Bucci, J.; Jakubek, J.; Pospisil, S.; Zaider, M.; Lerch, M. L. F.; Rosenfeld, A. B.; Petasecca, M. |
| Article Title: | BrachyView: Multiple seed position reconstruction and comparison with CT post-implant dosimetry |
| Abstract: | BrachyView is a novel in-body imaging system utilising high-resolution pixelated silicon detectors (Timepix) and a pinhole collimator for brachytherapy source localisation. Recent studies have investigated various options for real-time intraoperative dynamic dose treatment planning to increase the quality of implants. In a previous proof-of-concept study, the justification of the pinhole concept was shown, allowing for the next step whereby multiple active seeds are implanted into a PMMA phantom to simulate a more realistic clinical scenario. In this study, 20 seeds were implanted and imaged using a lead pinhole of 400 μ m diameter. BrachyView was able to resolve the seed positions within 1-2 mm of expected positions, which was verified by co-registering with a full clinical post-implant CT scan. © 2016 IOP Publishing Ltd and Sissa Medialab srl. |
| Keywords: | treatment planning; computerized tomography; dosimetry; intra-operative; proof of concept; silicon detectors; image resolution; dosimetry concepts and apparatus; instrumentation for gammaelectron therapy; intra-operative probes; x-ray detectors; pinhole collimators; position reconstruction; source localisation; x-ray detector |
| Journal Title: | Journal of Instrumentation |
| Volume: | 11 |
| Issue: | 5 |
| ISSN: | 1748-0221 |
| Publisher: | Institute of Physics Publishing Ltd. |
| Date Published: | 2016-01-01 |
| Start Page: | P05002 |
| Language: | English |
| DOI: | 10.1088/1748-0221/11/05/p05002 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 June 2016 -- Source: Scopus |
