Inherited susceptibility to pediatric acute lymphoblastic leukemia Journal Article
| Author: | Levine, R. L. |
| Article Title: | Inherited susceptibility to pediatric acute lymphoblastic leukemia |
| Abstract: | Although genome-wide analyses have identified somatic alterations contributing to the pathogenesis of pediatric acute lymphoblastic leukemia (ALL), few studies have identified germline variants conferring risk of this disease. Two reports now provide the first genome-wide glimpse into the role of inherited alleles in ALL pathogenesis. © 2009 Nature America, Inc. All rights reserved. |
| Keywords: | single nucleotide polymorphism; case-control studies; dna-binding proteins; polymorphism, single nucleotide; pathogenesis; cancer risk; allele; cancer susceptibility; genetic predisposition to disease; cohort studies; genetic variability; alleles; gene frequency; genetic variation; genome-wide association study; haplotypes; risk factors; acute lymphoblastic leukemia; transcription factors; oncogene proteins, fusion; cell line, transformed; precursor cell lymphoblastic leukemia-lymphoma; short survey; genome; childhood leukemia; germ-line mutation; ccaat-enhancer-binding proteins; cell transformation, viral; core binding factor alpha 2 subunit; herpesvirus 4, human; ikaros transcription factor |
| Journal Title: | Nature Genetics |
| Volume: | 41 |
| Issue: | 9 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2009-09-01 |
| Start Page: | 957 |
| End Page: | 958 |
| Language: | English |
| DOI: | 10.1038/ng0909-957 |
| PUBMED: | 19710713 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 30 November 2010" - "CODEN: NGENE" - "Source: Scopus" |
