Isocitrate dehydrogenase mutations in leukemia Journal Article
| Authors: | McKenney, A. S.; Levine, R. L. |
| Article Title: | Isocitrate dehydrogenase mutations in leukemia |
| Abstract: | Recent genome-wide discovery studies have identified a spectrum of mutations in different malignancies and have led to the elucidation of novel pathways that contribute to oncogenic transformation. The discovery of mutations in the genes encoding isocitrate dehydrogenase (IDH) has uncovered a critical role for altered metabolism in oncogenesis, and the neomorphic, oncogenic function of IDH mutations affects several epigenetic and gene regulatory pathways. Here we discuss the relevance of IDH mutations to leukemia pathogenesis, therapy, and outcome and how mutations in IDH1 and IDH2 affect the leukemia epigenome, hematopoietic differentiation, and clinical outcome. |
| Journal Title: | Journal of Clinical Investigation |
| Volume: | 123 |
| Issue: | 9 |
| ISSN: | 0021-9738 |
| Publisher: | American Society for Clinical Investigation |
| Date Published: | 2013-09-03 |
| Start Page: | 3672 |
| End Page: | 3677 |
| Language: | English |
| DOI: | 10.1172/jci67266 |
| PROVIDER: | scopus |
| PMCID: | PMC3754251 |
| PUBMED: | 23999441 |
| DOI/URL: | |
| Notes: | --- - Cited By (since 1996):1 - "Export Date: 1 October 2013" - "CODEN: JCINA" - "Source: Scopus" |
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