miR-124 regulates diverse aspects of rhythmic behavior in Drosophila Journal Article
| Authors: | Garaulet, D. L.; Sun, K.; Li, W.; Wen, J.; Panzarino, A. M.; O’Neil, J. L.; Robin Hiesinger, P.; Young, M. W.; Lai, E. C. |
| Article Title: | miR-124 regulates diverse aspects of rhythmic behavior in Drosophila |
| Abstract: | Circadian clocks enable organisms to anticipate and adapt to fluctuating environmental conditions. Despite substantial knowledge of central clock machineries, we have less understanding of how the central clock’s behavioral outputs are regulated. Here, we identify Drosophila miR-124 as a critical regulator of diurnal activity. During normal light/dark cycles, mir-124 mutants exhibit profoundly abnormal locomotor activity profiles, including loss of anticipatory capacities at morning and evening transitions. Moreover, mir-124 mutants exhibited striking behavioral alterations in constant darkness (DD), including a temporal advance in peak activity. Nevertheless, anatomical and functional tests demonstrate a normal circadian pacemaker in mir-124 mutants, indicating this miRNA regulates clock output. Among the extensive miR-124 target network, heterozygosity for targets in the BMP pathway substantially corrected the evening activity phase shift in DD. Thus, excess BMP signaling drives specific circadian behavioral output defects in mir-124 knock-outs. © 2016 the authors. |
| Keywords: | microrna; drosophila; circadian rhythm; bmp signaling; activity mode; activity phase |
| Journal Title: | The Journal of Neuroscience |
| Volume: | 36 |
| Issue: | 12 |
| ISSN: | 0270-6474 |
| Publisher: | Society for Neuroscience |
| Date Published: | 2016-03-23 |
| Start Page: | 3414 |
| End Page: | 3421 |
| Language: | English |
| DOI: | 10.1523/jneurosci.3287-15.2016 |
| PROVIDER: | scopus |
| PMCID: | PMC4804003 |
| PUBMED: | 27013671 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 May 2016 -- Source: Scopus |
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