BO-0742, a derivative of AHMA and N-mustard, has selective toxicity to drug sensitive and drug resistant leukemia cells and solid tumors Journal Article
| Authors: | Lee, C. H.; Chou, T. C.; Su, T. L.; Yu, J.; Shao, L. E.; Yu, A. L. |
| Article Title: | BO-0742, a derivative of AHMA and N-mustard, has selective toxicity to drug sensitive and drug resistant leukemia cells and solid tumors |
| Abstract: | This is a preclinical study of BO-0742, a derivative of 3-(9-acridinylamino)-5-hydroxymethyl-aniline (AHMA) and N-mustard, as an anti-cancer agent. MTS assays revealed a broad spectrum of anti-cancer activities in vitro, with the greatest cytotoxicity against leukemia and neuroblastoma including those with drug resistant characteristics, and a good therapeutic index with leukemia being 10-40 times more sensitive to BO-0742 than hematopoietic progenitors. Administration of BO-0742 at an optimal dose schedule based on its pharmacokinetics significantly suppressed the growth of xenografts of human breast and ovarian cancers in mice. Thus, BO-0742 is a potent anti-cancer agent worthy of further clinical development. © 2008 Elsevier Ireland Ltd. All rights reserved. |
| Keywords: | controlled study; human tissue; leukemia; unclassified drug; human cell; area under the curve; drug efficacy; liver cell carcinoma; nonhuman; antineoplastic agents; paclitaxel; antineoplastic agent; neoplasms; mouse; animals; mice; animal tissue; mus; ovary cancer; breast cancer; etoposide; animal experiment; antineoplastic activity; cancer cell culture; continuous infusion; cytotoxicity; in vitro study; drug resistance, neoplasm; xenograft model antitumor assays; cell line, tumor; cancer inhibition; human cell culture; drug distribution; neuroblastoma; hematopoietic stem cells; drug clearance; maximum plasma concentration; hematopoietic stem cell; 9 anilinoacridine derivative; aniline compounds; drug half life; drug sensitivity; acridines; bo-0742; n-mustard; pharmacokinetics; pre-clinical study; solid tumors; bo 0742; chlormethine derivative; mean residence time; plasma concentration-time curve; multidrug resistance-associated proteins; nitrogen mustard compounds; p-glycoprotein |
| Journal Title: | Cancer Letters |
| Volume: | 276 |
| Issue: | 2 |
| ISSN: | 0304-3835 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 2009-04-18 |
| Start Page: | 204 |
| End Page: | 211 |
| Language: | English |
| DOI: | 10.1016/j.canlet.2008.11.006 |
| PUBMED: | 19108949 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: CALED" - "Source: Scopus" |
