Hyperpolarization MRI preclinical models and potential applications in neuroradiology Journal Article
| Authors: | Miloushev, V. Z.; Keshari, K. R.; Holodny, A. I. |
| Article Title: | Hyperpolarization MRI preclinical models and potential applications in neuroradiology |
| Abstract: | Hyperpolarization is a novel technology that can dramatically increase signal to noise in magnetic resonance. The method is being applied to small injectable endogenous molecules, which can be used to monitor transient in vivo metabolic events, in real time. The emergence of hyperpolarized 13C-labeled probes, specifically 13C pyruvate, has enabled monitoring of core cellular metabolic events. Neuro-oncological applications have been demonstrated in preclinical models. Many more applications of this technology are envisioned, with transformative potential in magnetic resonance imaging. ©2016 Wolters Kluwer Health, Inc. |
| Keywords: | preclinical models; 13c pyruvate; brain tumor metabolism; hyperpolarization mri |
| Journal Title: | Topics in Magnetic Resonance Imaging |
| Volume: | 25 |
| Issue: | 1 |
| ISSN: | 0899-3459 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2016-02-01 |
| Start Page: | 31 |
| End Page: | 37 |
| Language: | English |
| DOI: | 10.1097/rmr.0000000000000076 |
| PROVIDER: | scopus |
| PUBMED: | 26848559 |
| PMCID: | PMC4968075 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 4 April 2016 -- Source: Scopus |
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