Hyperpolarization MRI preclinical models and potential applications in neuroradiology Journal Article


Authors: Miloushev, V. Z.; Keshari, K. R.; Holodny, A. I.
Article Title: Hyperpolarization MRI preclinical models and potential applications in neuroradiology
Abstract: Hyperpolarization is a novel technology that can dramatically increase signal to noise in magnetic resonance. The method is being applied to small injectable endogenous molecules, which can be used to monitor transient in vivo metabolic events, in real time. The emergence of hyperpolarized 13C-labeled probes, specifically 13C pyruvate, has enabled monitoring of core cellular metabolic events. Neuro-oncological applications have been demonstrated in preclinical models. Many more applications of this technology are envisioned, with transformative potential in magnetic resonance imaging. ©2016 Wolters Kluwer Health, Inc.
Keywords: preclinical models; 13c pyruvate; brain tumor metabolism; hyperpolarization mri
Journal Title: Topics in Magnetic Resonance Imaging
Volume: 25
Issue: 1
ISSN: 0899-3459
Publisher: Lippincott Williams & Wilkins  
Date Published: 2016-02-01
Start Page: 31
End Page: 37
Language: English
DOI: 10.1097/rmr.0000000000000076
PROVIDER: scopus
PUBMED: 26848559
PMCID: PMC4968075
DOI/URL:
Notes: Review -- Export Date: 4 April 2016 -- Source: Scopus
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  1. Andrei Holodny
    156 Holodny