| Authors: |
Wang, Z.; Seow, W. J.; Shiraishi, K.; Hsiung, C. A.; Matsuo, K.; Liu, J.; Chen, K.; Yamji, T.; Yang, Y.; Chang, I. S.; Wu, C.; Hong, Y. C.; Burdett, L.; Wyatt, K.; Chung, C. C.; Li, S. A.; Yeager, M.; Hutchinson, A.; Hu, W.; Caporaso, N.; Landi, M. T.; Chatterjee, N.; Song, M.; Fraumeni, J. F. Jr; Kohno, T.; Yokota, J.; Kunitoh, H.; Ashikawa, K.; Momozawa, Y.; Daigo, Y.; Mitsudomi, T.; Yatabe, Y.; Hida, T.; Hu, Z.; Dai, J.; Ma, H.; Jin, G.; Song, B.; Wang, Z.; Cheng, S.; Yin, Z.; Li, X.; Ren, Y.; Guan, P.; Chang, J.; Tan, W.; Chen, C. J.; Chang, G. C.; Tsai, Y. H.; Su, W. C.; Chen, K. Y.; Huang, M. S.; Chen, Y. M.; Zheng, H.; Li, H.; Cui, P.; Guo, H.; Xu, P.; Liu, L.; Iwasaki, M.; Shimazu, T.; Tsugane, S.; Zhu, J.; Jiang, G.; Fei, K.; Park, J. Y.; Kim, Y. H.; Sung, J. S.; Park, K. H.; Kim, Y. T.; Jung, Y. J.; Kang, C. H.; Park, I. K.; Kim, H. N.; Jeon, H. S.; Choi, J. E.; Choi, Y. Y.; Kim, J. H.; Oh, I. J.; Kim, Y. C.; Sung, S. W.; Kim, J. S.; Yoon, H. I.; Kweon, S. S.; Shin, M. H.; Seow, A.; Chen, Y.; Lim, W. Y.; Liu, J.; Wong, M. P.; Lee, V. H. F.; Bassig, B. A.; Tucker, M.; Berndt, S. I.; Chow, W. H.; Ji, B. T.; Wang, J.; Xu, J.; Sihoe, A. D. L.; Ho, J. C. M.; Chan, J. K. C.; Wang, J. C.; Lu, D.; Zhao, X.; Zhao, Z.; Wu, J.; Chen, H.; Jin, L.; Wei, F.; Wu, G.; An, S. J.; Zhang, X. C.; Su, J.; Wu, Y. L.; Gao, Y. T.; Xiang, Y. B.; He, X.; Li, J.; Zheng, W.; Shu, X. O.; Cai, Q.; Klein, R.; Pao, W.; Lawrence, C.; Hosgood, H. D. 3rd; Hsiao, C. F.; Chien, L. H.; Chen, Y. H.; Chen, C. H.; Wang, W. C.; Chen, C. Y.; Wang, C. L.; Yu, C. J.; Chen, H. L.; Su, Y. C.; Tsai, F. Y.; Chen, Y. S.; Li, Y. J.; Yang, T. Y.; Lin, C. C.; Yang, P. C.; Wu, T.; Lin, D.; Zhou, B.; Yu, J.; Shen, H.; Kubo, M.; Chanock, S. J.; Rothman, N.; Lan, Q. |
| Article Title: |
Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women |
| Abstract: |
Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10-13), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10-10) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10-9). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings. © The Author 2015. Published by Oxford University Press. All rights reserved. |
| Journal Title: |
Human Molecular Genetics
|
| Volume: |
25 |
| Issue: |
3 |
| ISSN: |
0964-6906 |
| Publisher: |
Oxford University Press
|
| Date Published: |
2016-02-01 |
| Start Page: |
620 |
| End Page: |
629 |
| Language: |
English |
| DOI: |
10.1093/hmg/ddv494
|
| PROVIDER: |
scopus
|
| PMCID: |
PMC4731021
|
| PUBMED: |
26732429
|
| DOI/URL: |
|
| Notes: |
Article -- Export Date: 4 April 2016 -- Source: Scopus |
