Genome-wide association study identifies multiple loci associated with bladder cancer risk Journal Article
| Authors: | Figueroa, J. D.; Ye, Y.; Siddiq, A.; Garcia-Closas, M.; Chatterjee, N.; Prokunina-Olsson, L.; Cortessis, V. K.; Kooperberg, C.; Cussenot, O.; Benhamou, S.; Prescott, J.; Porru, S.; Dinney, C. P.; Malats, N.; Baris, D.; Purdue, M.; Jacobs, E. J.; Albanes, D.; Wang, Z.; Deng, X.; Chung, C. C.; Tang, W.; Bas bueno-de-mesquita, H.; Trichopoulos, D.; Ljungberg, B.; Clavel-Chapelon, F.; Weiderpass, E.; Krogh, V.; Dorronsoro, M.; Travis, R.; Tjønneland, A.; Brenan, P.; Chang-Claude, J.; Riboli, E.; Conti, D.; Gago-Dominguez, M.; Stern, M. C.; Pike, M. C.; Van den Berg, D.; Yuan, J.; Hohensee, C.; Rodabough, R.; Cancel-Tassin, G.; Roupret, M.; Comperat, E.; Chen, C.; De Vivo, I.; Giovannucci, E.; Hunter, D. J.; Kraft, P.; Lindstrom, S.; Carta, A.; Pavanello, S.; Arici, C.; Mastrangelo, G.; Kamat, A. M.; Lerner, S. P.; Barton grossman, H.; Lin, J.; Gu, J.; Pu, X.; Hutchinson, A.; Burdette, L.; Wheeler, W.; Kogevinas, M.; Tardón, A.; Serra, C.; Carrato, A.; García-closas, R.; Lloreta, J.; Schwenn, M.; Karagas, M. R.; Johnson, A.; Schned, A.; Armenti, K. R.; Hosain, G. M.; Andriole, G.; Grubb, R.; Black, A.; Ryan Diver, W.; Gapstur, S. M.; Weinstein, S. J.; Virtamo, J.; Haiman, C. A.; Landi, M. T.; Caporaso, N.; Fraumeni, J. F.; Vineis, P.; Wu, X.; Silverman, D. T.; Chanock, S.; Rothman, N. |
| Article Title: | Genome-wide association study identifies multiple loci associated with bladder cancer risk |
| Abstract: | Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 bladder cancer cases and 5751 controls, followed by a meta-analysis with two independently published bladder cancer GWAS, resulting in a combined analysis of 6911 cases and 11 814 controls of European descent. TaqMan genotyping of 13 promising single nucleotide polymorphisms with P < 1 × 10-5 was pursued in a follow-up set of 801 cases and 1307 controls. Two new loci achieved genome-wide statistical significance: rs10936599 on 3q26.2 (P = 4.53 × 10-9) and rs907611 on 11p15.5 (P = 4.11 × 10-8). Two notable loci were also identified that approached genome-wide statistical significance: rs6104690 on 20p12.2 (P = 7.13 × 10-7) and rs4510656 on 6p22.3 (P = 6.98 × 10-7); these require further studies for confirmation. In conclusion, our study has identified new susceptibility alleles for bladder cancer risk that require fine-mapping and laboratory investigation, which could further understanding into the biological underpinnings of bladder carcinogenesis. |
| Journal Title: | Human Molecular Genetics |
| Volume: | 23 |
| Issue: | 5 |
| ISSN: | 0964-6906 |
| Publisher: | Oxford University Press |
| Date Published: | 2014-03-01 |
| Start Page: | 1387 |
| End Page: | 1398 |
| Language: | English |
| DOI: | 10.1093/hmg/ddt519 |
| PROVIDER: | scopus |
| PMCID: | PMC3919005 |
| PUBMED: | 24163127 |
| DOI/URL: | |
| Notes: | Export Date: 3 March 2014 -- CODEN: HMGEE -- Source: Scopus |
