Cancer-treatment-induced neurotoxicity - Focus on newer treatments Journal Article
| Authors: | Stone, J. B.; DeAngelis, L. M. |
| Article Title: | Cancer-treatment-induced neurotoxicity - Focus on newer treatments |
| Abstract: | Neurotoxicity caused by traditional chemotherapy and radiotherapy is widely recognized in patients with cancer. The adverse effects of newer therapeutics, such as biological and immunotherapeutic agents, are less well established, and are associated with considerable neurotoxicity in the central and peripheral nervous systems. This Review addresses the main neurotoxicities of cancer treatment with a focus on the newer therapeutics. Recognition of these patterns of toxicity is important because drug discontinuation or dose adjustment might prevent further neurological injury. Knowledge of these toxicities also helps to differentiate treatment-related symptoms from progression of cancer or its involvement of the nervous system. Familiarity with the neurological syndromes associated with cancer treatments enables clinicians to use the appropriate treatment for the underlying malignancy while minimizing the risk of neurological damage, which might preserve patients' quality of life. © 2016 Macmillan Publishers Limited. |
| Keywords: | cancer chemotherapy; constipation; review; angiogenesis inhibitor; bevacizumab; cisplatin; cancer growth; drug efficacy; drug penetration; drug safety; drug withdrawal; hypertension; risk benefit analysis; treatment duration; pathophysiology; gemcitabine; cancer radiotherapy; radiation dose; cytarabine; methotrexate; rituximab; temozolomide; drug megadose; neurotoxicity; nuclear magnetic resonance imaging; outcome assessment; positron emission tomography; antineoplastic agent; ipilimumab; unindexed drug; melanoma; quality of life; bortezomib; multiple myeloma; sensory neuropathy; breast cancer; nausea; myalgia; peripheral neuropathy; extrapyramidal symptom; orthostatic hypotension; vincristine; plasmapheresis; antineoplastic activity; chronic myeloid leukemia; radiation injury; thiotepa; hodgkin disease; irinotecan; dizziness; cerebrovascular disease; blood brain barrier; lymphoma; ovary carcinoma; brain disease; muscle weakness; ondansetron; mental disease; malignant neoplastic disease; platinum derivative; seizure; headache; immunomodulating agent; vinca alkaloid; vestibular disorder; large cell lymphoma; kaposi sarcoma; high risk population; second cancer; motor dysfunction; oxaliplatin; neurologic disease; metoclopramide; ataxia; follicular lymphoma; brain hemorrhage; inappropriate vasopressin secretion; facial nerve paralysis; visual impairment; hearing impairment; cyclosporin; jaw disease; retinoid; artery thrombosis; leukoencephalopathy; radiation necrosis; biological product; cranial neuropathy; spinal cord disease; cerebrovascular accident; muscle cramp; ptosis; hairy cell leukemia; hoarseness; metastatic melanoma; duloxetine; randomized controlled trial (topic); phase 3 clinical trial (topic); otitis media; posterior reversible encephalopathy syndrome; myositis; aseptic meningitis; dysarthria; intracranial hypertension; anosmia; nelarabine; dystonia; parkinsonism; myelitis; demyelinating disease; motor neuron disease; plexopathy; cerebellum disease; tardive dyskinesia; recombinant alpha interferon; acute brain disease; cerebral sinus thrombosis; brentuximab vedotin; pyridostigmine; human; priority journal; bulbar paralysis; neuromuscular junction disorder; recombinant asparaginase; acute inflammatory demyelinating polyneuropathy; athetosis; chronic inflammatory demyelinating polyneuropathy; extraocular palsy; smart syndrome; spinal cord syndrome |
| Journal Title: | Nature Reviews Clinical Oncology |
| Volume: | 13 |
| Issue: | 2 |
| ISSN: | 1759-4774 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2016-02-01 |
| Start Page: | 92 |
| End Page: | 105 |
| Language: | English |
| DOI: | 10.1038/nrclinonc.2015.152 |
| PROVIDER: | scopus |
| PUBMED: | 26391778 |
| PMCID: | PMC4979320 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 March 2016 -- Source: Scopus |
