Cerebellar EBV-associated diffuse large B cell lymphoma following angioimmunoblastic T cell lymphoma Journal Article
| Authors: | Zhou, Y.; Rosenblum, M. K.; Dogan, A.; Jungbluth, A. A.; Chiu, A. |
| Article Title: | Cerebellar EBV-associated diffuse large B cell lymphoma following angioimmunoblastic T cell lymphoma |
| Abstract: | Epstein-Barr virus (EBV)-associated B cell lymphoproliferative disorders may be seen in patients with angioimmunoblastic T cell lymphoma (AITL). Although both nodal and extranodal sites of involvement have been described, central nervous system involvement by B cell lymphoma following AITL has not previously been documented. We report a first example of such unusual presentation, in which an 80-year-old man developed diffuse large B cell lymphoma (DLBCL) in the cerebellum 4 months after the initial diagnosis of AITL. EBV-encoded RNAs were detected in the DLBCL, suggesting that EBV played a pivotal role in the pathogenesis of high-grade histologic progression of AITL. The patient survived less than 9 months after his initial diagnosis of AITL. We believe that this case expands the spectrum of extranodal manifestation of EBV-positive B cell lymphoma associated with AITL and illustrates the importance of recognition of this association when encountering unusual central nervous system lesions in patients with known AITL. © 2015, Springer-Verlag Berlin Heidelberg. |
| Keywords: | central nervous system; diffuse large b cell lymphoma; angioimmunoblastic t cell lymphoma |
| Journal Title: | Journal of Hematopathology |
| Volume: | 8 |
| Issue: | 4 |
| ISSN: | 1868-9256 |
| Publisher: | Springer |
| Date Published: | 2015-12-01 |
| Start Page: | 235 |
| End Page: | 241 |
| Language: | English |
| DOI: | 10.1007/s12308-015-0241-8 |
| PROVIDER: | scopus |
| PMCID: | PMC4993208 |
| PUBMED: | 27559423 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 March 2016 -- Source: Scopus |
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